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Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients
Background: Bispecific T-cell Engagers (TCEs) targeting B7H3 (CD276) show promise for solid tumors but are limited by systemic toxicities and poor tumor penetration. Intratumoral (IT) delivery is proposed as a solution, but the safety and spatial pharmacodynamics (PD) remain poorly defined in these malignancies. Spontaneous canine tumors serve as a highly translatable model for human therapeutic development due to its clinical, genetic, and immunological similarities to human patients.
EMB 00.01 FRI Andrew Mountbatten-Windsor sublet Royal Lodge cottages to boost private income – despite paying peppercorn rent
EMB 00.01 FRI Andrew Mountbatten-Windsor sublet Royal Lodge cottages to boost private income – despite paying peppercorn rent The former prince gained income from privately subletting three cottages within Royal Lodge, a new report from the National Audit Office shows - Bookmark - CommentsGo to comments Andrew Mountbatten-Windsor sublet three properties on the Royal Lodge estate to boost his private income for more than 20 years – despite paying a “peppercorn rent” himself, a new audit...
One Transit Is All You Need: Detecting Exoplanets Through Learned Stellar Behaviour with EXOVEIL
arXiv:2606.02778v1 Announce Type: cross Abstract: I present EXOVEIL, a transit detection system that learns what a star's brightness should look like and flags when reality disagrees. Unlike existing systems that require phase-folded input, EXOVEIL operates on raw flux time series and can detect planets that transit only once. A Transformer world model, trained on 16,499 Kepler light curves with transit-masked self-supervised learning, predicts expected stellar flux.
ActProbe: Action-Space Probe for Early Failure Detection of Generative Robot Policies
arXiv:2606.08508v1 Announce Type: new Abstract: Generative robot policies fail unpredictably at deployment: they hesitate at critical moments, drift off-task, or commit to unrecoverable actions. Existing online failure detectors either require white-box access to policy internals or add runtime overhead through resampling and observation-side signals. Our empirical analysis shows that emitted action chunks themselves already carry strong predictive signal for impending failures in generative...
One Transit Is All You Need: Detecting Exoplanets Through Learned Stellar Behaviour with EXOVEIL
arXiv:2606.02778v2 Announce Type: replace-cross Abstract: I present EXOVEIL, a transit detection system that learns what a star's brightness should look like and flags when reality disagrees. Unlike existing systems that require phase-folded input, EXOVEIL operates on raw flux time series and can detect planets that transit only once. A Transformer world model, trained on 16,499 Kepler light curves with transit-masked self-supervised learning, predicts expected stellar flux.