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SOD1 Catalyses Thiol Oxidation to Thiosulfinates
Cu/Zn superoxide dismutase (SOD1) is canonically regarded as a superoxide scavenging antioxidant yet is paradoxically associated with multiple diseases. Here, we show that SOD1 catalyzes thiol oxidation to thiosulfinates (RS(O)SR), revealing a previously unrecognized copper mediated oxidant forming reaction in biology. Steady state kinetics demonstrate robust, O2 dependent thiol consumption, and ATR FTIR spectra of the SOD1-cysteine reaction display S--O bands ({approx}1042/1169 cm-1)...