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A Crossed Laser Phase Plate for CryoEM

The laser phase plate (LPP) enables phase-contrast imaging in cryogenic electron microscopy (cryoEM), enhancing image contrast without compromising high-resolution information. Here we report the implementation of a crossed laser phase plate (xLPP) comprising two optical cavities oriented orthogonally, installed in a ThermoFisher Scientific Krios G4 microscope equipped with a newly designed transfer lens module. We demonstrate the expected, strong contrast enhancement and stable, additive...

bioRxiv 5d ago

Taxpayer-funded 'Meth Mansion' under fire as crime concerns mount around homeless campus

A Los Angeles County-funded homeless services campus dubbed a "Meth Mansion" by critics is facing mounting scrutiny after residents, business leaders and law enforcement officials raised alarms about violence, drug activity and public safety concerns surrounding the facility. The Skid Row Care Campus, located at 442 S. Crocker Street in downtown Los Angeles, was approved by county officials as part of a broader effort to address homelessness in Skid Row. Public records reviewed by Fox News...

Fox News 8d ago

Housing First is a disaster. I saw Sacramento's homeless chaos firsthand

America’s homelessness crisis is routinely framed as a housing crisis. It is a crisis born from the collapse of accountability at every level of the system. Nowhere are the consequences of that collapse more visible than in California — and especially in its capital city, Sacramento.

Fox News 9d ago

Life in the ancient Arctic: Tiny teeth of newly discovered species suggest it was a cradle of mammalian evolution

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Phys.org 7d ago

Out-of-plane ice bridges reveal new way to suppress frost spreading

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Phys.org 6d ago

Deep learning four decades of human migration

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Nature 17h ago

Vance refers Minnesota officials to DOJ for criminal fraud investigation

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The Independent World 22h ago