TPR Domains Drive
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Related Articles from SNS
TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70
HOP is a cochaperone that facilitates client transfer between two major chaperones, Hsp90 and Hsp70. Emerging evidence, however, suggests that HOP plays additional roles in coordinating complex proteostasis networks. We demonstrate here that stress-dependent HOP foci are biomolecular condensates formed by liquid-liquid phase separation.