Target of Rapamycin Complex 1
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Sphingolipids integrate TORC2 with TORC1 through vacuolar liquid-ordered domain formation
The coordination of multiple signaling pathways across different compartments of the endomembrane system is essential for cellular adaptation to the environment; however, the underlying mechanisms remain poorly understood. Previous studies have described the existence of sterol-enriched liquid-ordered (Lo) domains in the vacuole membrane of yeast, which act as platforms for signal initiation. Here, we demonstrate that vacuolar Lo domains serve as signaling platforms for the evolutionarily...
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.