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TB vaccine from the 1920s shows promise in diabetes trial
Nature, Published online: 09 June 2026; doi:10.1038/d41586-026-01825-wThe shot reduced insulin use for people with type 1 diabetes and another autoimmune condition.
Calorie Restriction-Induced Daily Hibernation in Mice Drives Cyclic DNA Damage and Repair
Hibernation consists of bouts of torpor, characterized by profound decreases in metabolism and body temperature (Tb), alternated with periods of euthermia called interbout arousals, during which normal metabolism and Tb resume. Seasonal hibernators accumulate DNA strand breaks during torpor, which are repaired during arousal. Here, we assess dynamics of DNA damage and repair during serial daily torpor in mice induced by 30% calorie restriction (CR) and investigate the effects of metabolic...
PgDog is funded and coming to a database near you
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Clustering Guided Domain-Specific Pretrained Foundation Model Very High-Resolution Arctic Remote Sensing
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Can China fill funding and leadership gaps after America quit the WHO?
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Researchers discover how to turn one germ's drug resistance into an Achilles' heel
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Is the peptide craze backed by science? The promise behind the hype
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Preventing the Breakdown of Tight-Binding Waveguide Optics by L\"owdin Orthogonalization
arXiv:2605.31074v1 Announce Type: new Abstract: Many advancements in optics have relied on the tight-binding approximation, which simplifies the description and prediction of complex system behaviors. This approximation describes the dynamics of the total light field by examining the coupling between the guided modes of individual single-mode substructures -- also known as coupled mode theory. However, the underlying assumption, that the guided modes of individual waveguides form an...
Replicate-anchored calibration of within-host single nucleotide variant detection in Mycobacterium tuberculosis whole genome sequencing
Intra-host genetic heterogeneity in Mycobacterium tuberculosis is biologically and clinically informative, but its detection from short read whole genome sequencing depends on thresholds over read depth (DP), alternate allele support (AD), and minor allele frequency (MAF) that are rarely empirically anchored. We developed a biological replicate-anchored, lexicographic calibration framework for per-specimen intra-host single nucleotide variant (iSNV) detection. Within-patient replicate sputum...