Technological Fitness and Regional Growth
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Technological Fitness and Regional Growth in Japan
Announce Type: new Abstract: Technological knowledge plays an important role in shaping regional economic performance. This study examines the relationship between the sophistication of regional technological capabilities and economic growth across Japanese prefectures. Using approximately 3.9 million corporate patent records filed from fiscal years 1981 to 2015, we construct bipartite networks linking 47 prefectures to 35 technology classes and apply the Fitness-Complexity algorithm to...
Will Australia be taken for a ride in the AI and data centre boom?
analysis In the great data centre boom, will the benefits flow offshore again? Sun 7 Jun 2026 at 4:40am On the corner of Mamre Road and the yet-to-be-built South Link Road, in the western Sydney suburb of Kemps Creek, plans are afoot that could change the way the world works. It's here, in this picturesque semi-rural expanse, wedged between Sydney's rapidly growing outer suburbs and the new international airport at Badgerys Creek, that the AI boom has landed in Australia, with a thud.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...