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Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis
Tertiary lymphoid structures (TLSs) are sites of immune organization in peripheral tissues that arise from chronic inflammation. They play important roles in infection control and cancer but the mechanisms controlling their formation remain only partly understood. Here, we combine high-plex imaging, serial-section 3D reconstruction, and optimal transport trajectory modeling to reconstruct TLSs in human lungs infected with Mycobacterium tuberculosis.
GDP rose 7.7% in FY26, 7.8% in Q4; RBI trims this year's projection to 6.6%
The Indian economy grew 7.8% in the Jan-March quarter as strong investment, sustained farm production and expansion of the construction and tertiary sector led to a robust demand, offsetting the anticipated adverse impact of the conflict in West Asia. Data released by the National Statistics Office (NSO) Friday with the revised 2022-23 base year estimated 2025-26 growth at 7.7%, compared with 7.6% in the second advance estimates released in Feb. This is comparably higher than the 7.1% growth...
Structure of a dopamine-binding RNA aptamer reveals metal-mediated ligand recognition
The selection of small-molecule binding RNA aptamers enables the creation of ligand-responsive RNA tools, yet most aptamers fail to operate reliably across diverse environments. Scaffolded selection addresses this limitation by preserving the tertiary architecture of a riboswitch scaffold while driving the evolution of a new ligand-binding pocket. Using the xpt purine riboswitch aptamer, we previously generated dopamine-binding aptamers.
Why 8 in 10 patients turn to internet after doctor visits
NEW DELHI: India’s healthcare system is facing a growing “patient confusion crisis”, with nearly eight out of 10 patients in Delhi-NCR turning to Google or social media after visiting doctors because they leave consultations without fully understanding their illness, treatment or next steps, according to a survey released on Sunday. The India Patient Navigation and Confusion Index (IPNCI), 2026, was conducted among 1,000 respondents across Delhi, Noida, Gurgaon, Faridabad and Ghaziabad. It...
Secondary silylium ion drives one-pot ketone sulfonamidation, reaching 95% yields
Secondary silylium ion drives one-pot ketone sulfonamidation, reaching 95% yields Lisa Lock Scientific Editor Andrew Zinin Lead Editor A research team has developed a novel organocatalysis method based on a silylium Lewis acid. This technology employs an ion-pair catalyst combining a diethylsilylium ion with a weakly coordinating anion, enabling the direct installation of sulfonamide groups into functionalized ketone compounds, including β-ketoesters, which had previously been difficult to...
ICAC to probe allegations against University of Wollongong executives
ICAC inquiry to probe conflict of interest, favouritism allegations against University of Wollongong executives Tue 2 Jun 2026 at 4:27pm In short: The Independent Commission Against Corruption is to investigate allegations relating to the University of Wollongong. The Commission will probe allegations against Chancellor Michael Still and around the employment of consultancy firm KordaMentha. The hearings will start on June 22.
Great mysteries of archaeology: An ancient Amazonian world revealed from the sky
Great mysteries of archaeology: An ancient Amazonian world revealed from the sky Gaby Clark Scientific Editor Andrew Zinin Lead Editor From the air, you see it only through the constant jolt, tilt, and shudder of the low-flying Cessna aircraft. The landscape of the Llanos de Moxos, northern Bolivia, appears as a disconnected patchwork of open grassland savannahs, forest islands, and lakes. It feels random, almost unreadable.
Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease
Renal fibrosis is the common final pathway of chronic kidney disease (CKD), driven in part by myofibroblast-mediated extracellular matrix deposition. M2 macrophages have been implicated as a source of myofibroblasts through macrophage-to-myofibroblast transition (MMT), yet whether M2 macrophages are pro- or anti-fibrotic remains controversial, and the spatial context in which MAC-M2-fibrosis coupling occurs is unknown. Here, we applied geographically weighted regression (GWR), a spatial...
Co-delivered PD-L1 rescues the protective efficacy mediated by an AAV-expressed HIV-1 bNAb
Adeno-associated virus (AAV)-delivered anti-HIV-1 broadly neutralizing antibodies (bNAbs) could prevent and treat HIV-1 infection but are limited by host immune responses, specifically anti-drug antibodies (ADA). We tested whether PD-L1-mediated immune shielding could improve the consistency of AAV-delivered bNAb expression from muscle tissue in rhesus macaques. AAV9.PD-L1 co-delivery with AAV9.3BNC117 reduced the occurrence of ADA and T cell responses and improved the durability of 3BNC117...
Notre Dame university halts new nursing student enrolments for another year
The University of Notre Dame Australia will not take new students for its nursing program for another year, leaving many students in limbo. Some students had enrolled in health science units after the program was cancelled for the first semester of the year, in the hope of enrolling for the second semester of 2026. One student who contacted the ABC said they were "devastated" by the news, and felt as though they had "wasted a year of life" at the university.