The European Stability Mechanism
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Greece gets green light to repay €6.95bn of bailout loans early
Greece has been cleared to repay almost €7bn of bailout loans ahead of schedule, in a move European officials say will improve the country's debt position. The European Stability Mechanism (ESM) has approved Greece's request to repay €6.95 billion of loans early under the first bailout programme through the Greek Loan Facility (GLF). The loans were part of the international rescue packages agreed during Greece's debt crisis in 2010.
Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
EU proposes freezing Russian oil price cap to prevent windfall for Kremlin’s war chest
BRUSSELS — The EU will propose freezing the adjustment mechanism in its oil price cap on Russian crude to prevent it from rising with global benchmarks, European Commission President Ursula von der Leyen said on Tuesday. That would stop Russia from benefiting from the rise in oil prices resulting from Iran’s closure of the Strait of Hormuz. Presenting the EU’s 21st package of sanctions on Russia, Von der Leyen explained that “our oil price cap has a built-in adjustment mechanism to...
Türkiye, Singapore among countries rejecting ‘strategic resignation’ amid global disorder, says Turkish foreign minister
Türkiye, Singapore among countries rejecting ‘strategic resignation’ amid global disorder, says Turkish foreign minister Speaking at a special lecture in Singapore, Minister Hakan Fidan touched on Israel and the Middle East conflict, finding alternative connectivity routes to the Straits of Hormuz and Ankara’s foreign policy approach in Southeast Asia. SINGAPORE: Türkiye and Singapore are among “a handful of wise and responsible nations” which have rejected “strategic resignation” amid a...
Mozart the idol: Searching for beauty in times of crisis
Mozart the idol: Searching for beauty in times of crisis June 1, 2026When the world seems to be falling apart, people look for something to hold on to. "Now, more than ever, with the world plagued by crises and at risk of being engulfed by war, there is a growing desire for unity," says Evelyn Meining, artistic director of the Mozartfest Würzburg. Throughout history, the genius and beauty of Wolfgang Amadeus Mozart's music has frequently provided comfort during times of crisis — and it...
Locked-in food system slows Europe's green shift, article warns
Locked-in food system slows Europe's green shift, article warns Gaby Clark Scientific Editor Andrew Zinin Lead Editor Europe's agrifood system is under severe pressure. Climate change is causing droughts and floods, and agriculture is putting pressure on nature, the climate and the environment. Diet-related lifestyle diseases are placing a growing burden on health care systems.
Nine decades of changing insect diversity in Switzerland expose a striking divide
Nine decades of changing insect diversity in Switzerland expose a striking divide Lisa Lock Scientific Editor Robert Egan Associate Editor Thanks to a historical data archive, Swiss researchers are able to draw conclusions about the changes in the diversity of two insect groups over the past 90 years. The study, led by Agroscope, identified a significant decline in butterflies and deadwood beetle species around the middle of the 20th century. These groups live predominantly in agricultural...
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...