The Guide #244:
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The Guide #244: From Chinese microdramas to an Arctic comedy – what the world is watching
In the newsletter: Our global writers share the shows captivating local audiences, from Côte d’Ivoire’s hottest soap to the next best thing out of Canada since Heated Rivalry• Don’t get The Guide delivered to your inbox? Sign up hereIt’s high time for another of our occasional glances at what the world is watching; the TV popular on the beats covered by some of the Guardian’s many global correspondents. Last time we asked our reporters in Brazil, Jamaica, Japan, Nigeria and Poland, and heard...
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.