The Information Bonus of AlphaFold2 Representations
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When Does Structure Help? The Information Bonus of AlphaFold2 Representations over Protein Language Models
arXiv:2606.04228v1 Announce Type: new Abstract: AI scientist systems increasingly choose biological foundation models before they choose experiments. In protein pipelines, this creates a concrete engineering and scientific question: when is the cost of structural inference worth paying over a cheaper sequence-only model? We introduce the information bonus (IB), a task-level metric that measures the linearly accessible advantage of frozen single-sequence AlphaFold2 Evoformer representations...