Transcriptional
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Court system 'in a shambles' after transcription service goes bust
Court transcription company VIQ Solutions to be shut down, mass redundancies expected Fri 5 Jun 2026 at 12:52pm There are fears mass redundancies at Australia's main transcription service could leave court cases around the country in limbo after it was revealed VIQ Solutions would be wound down. The ABC understands all VIQ Solutions court transcribers are expected to be made redundant and no further orders for transcripts will be accepted through its portal. However, the Federal Court said...
Simulation of transcription factor clustering in nuclei from molecular kinetics
Transcription factors form clusters often described as condensates that exhibit emergent biophysical properties. Here we present a software package to simulate transcription factor spatial distributions from molecular diffusion and binding kinetics alone. The software simulates microscopy data and FRAP experiments and recapitulates the clustering behavior of experimentally characterized transcription factors.
Differential Transcript Usage Reveals Isoform-Level Remodeling of Tumor Biology in Clear Cell Renal Cell Carcinoma
Clear cell renal cell carcinoma (ccRCC) is characterized by transcriptional reprogram-ming driven by hypoxia signaling, metabolic rewiring, and immune modulation. While gene-level analyses have defined key features of ccRCC biology, they do not capture isoform-level variation arising from alternative splicing. Differential transcript usage (DTU) represents an additional regulatory layer that may influence protein function, pathway activity, and clinical outcomes, yet its role in ccRCC...
Short single-stranded DNA oligonucleotides enable intracellular transcription of functional RNAs in mammalian cells
Programmable intracellular production of short functional RNAs underlies diverse applications ranging from gene regulation to genome engineering, but is often constrained by cloning workflows, RNA synthesis, or viral-vector delivery. Here, we introduce a single-stranded DNA (ssDNA)-driven intracellular transcription strategy in which short ssDNA templates function as transcriptional substrates when paired with orthogonal bacteriophage RNA polymerases (RNAPs). By embedding phage promoters...
Pam Bondi puts Todd Blanche on the hook for ‘entire release’ of the Epstein files, transcript reveals
Pam Bondi puts Todd Blanche on the hook for ‘entire release’ of the Epstein files, transcript reveals The former AG says she wasn’t ‘placing blame’ on her successor after lawmakers accused her of throwing him under the bus - Bookmark Former Attorney General Pam Bondi said “I don’t recall” at least 34 times during her closed-door interview with members of Congress investigating Jeffrey Epstein, a transcript of the meeting reveals. Bondi, who was fired by Donald Trump in April, repeatedly told...
A global regulatory atlas of Streptomyces reveals conserved and diversified transcriptional networks across actinomycetes
Transcriptional regulatory networks determine how bacteria integrate environmental signals with growth, metabolism and stress adaptation. Actinomycetes encode exceptionally large repertoires of transcription factors (TFs) coordinating morphological development, environmental adaptation and specialized metabolism, yet their regulatory networks remain poorly defined. Here, we apply DNA affinity purification sequencing (DAP-seq) to 789 predicted TFs of Streptomyces coelicolor, generating...
RE-1 silencing transcription factor is reduced in endometriosis and uterine deletion in mice alters progesterone responsiveness
Endometriosis is a steroid-dependent gynecologic disease characterized by progesterone (P4) resistance, subfertility/infertility, and pelvic pain; however, the molecular mechanisms underlying impaired P4 responsiveness in endometriosis tissue are not fully understood. RE-1 silencing transcription factor (REST), a transcriptional regulator implicated in steroid hormone signaling, has emerged as a potential mediator of P4 responsiveness. Here, we investigated the role of REST in endometriosis...
Transcriptionally Active HIV Reservoirs Enriched for Interferon-Inducible APOBEC3-Related Mutational Signatures Associate with Reduced Neuroaxonal Integrity
Despite sustained viral suppression with effective antiretroviral therapy (ART), neuroaxonal integrity persist in a subset of people with HIV-1 (PWH). We investigated whether interferon (IFN)-inducible APOBEC3-associated mutational signatures, reflected by premature stop codons (PSCs), and reservoir-associated drug resistance mutations (RS-DRMs) within transcriptionally active HIV-1 reservoirs influence neuroaxonal integrity in fully virally suppressed individuals. Peripheral CD4 T cells...
Do You Actually Need to Pay for Transcription Software?
I'm constantly seeing ads for Wispr Flow, an AI-powered transcription tool. The pitch—that you'll be able to write faster by talking out loud instead of typing—is compelling, especially if you're a slow typist. The marketing promises you'll be able to "write at the speed of thought, 4x faster than your keyboard."
ATML1-GIR1-TPL/TPR transcriptional repression module controls glucosinolates and giant cells in Arabidopsis thaliana sepals
Glucosinolates (GSLs) are sulfur- and nitrogen-containing secondary metabolites that serve as defense compounds in Arabidopsis and other members of the Brassicales. Although the enzymatic pathway that produces GSLs is well-studied, the upstream mechanisms that control their tissue-specific synthesis are poorly understood. We identified a novel repression module that transcriptionally regulates GSL levels in sepals, the modified leaves that protect reproductive tissues within the floral bud.