V K Singh
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SC: Can’t use OSA to deny accused access to documents relied on by prosecution
Holding that it is part of an accused’s right to fair trial that he gets access to documents relied upon by the prosecution, Supreme Court has said invocation of the Official Secrets Act (OSA) cannot take away the right of the accused person to get copies of the documents forming part of the chargesheet even if they are highly classified and confidential pertaining to national security. A bench of Justices J K Maheshwari and Atul S Chandurkar directed the Centre to provide the alleged secret...
Diagnostic dilemma: Doctors couldn't explain why a boy was bleeding from his eyes, ears and nose
Diagnostic dilemma: Doctors couldn't explain why a boy was bleeding from his eyes, ears and nose A case of a boy who bled from his eyes eventually led doctors to a diagnosis that has been reported fewer than 50 times in the medical literature. The patient: An 11-year-old boy in India The symptoms: The boy's parents brought him to a hospital after he had several episodes of bleeding from his eyes, nose and ears. The episodes, which had occurred for about a month, seemed to start for no...
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...