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Molecular pet or parasite? Exploring selection for vertical and horizontal plasmid transfer

Understanding the environmental conditions that drive selection for increased horizontal plasmid transfer is crucial for predicting the spread of plasmid-encoded antibiotic resistance. In natural systems, plasmids exhibit diverse lifestyles, ranging from "host-centric" strategies, which favor vertical gene transfer (VGT) from mother to daughter cell at the expense of horizontal mobility, to "parasitic" strategies, which favor horizontal gene transfer (HGT) by conjugation at the expense of...

bioRxiv 8d ago