Von Willebrand
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Related Articles from SNS
Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in Von Willebrand Factor
The large glycoprotein von Willebrand factor (VWF) is essential for primary hemostasis. By sensing hydrodynamic forces in the bloodstream, VWF elongates under elevated shear, increasing its adhesiveness to platelets. This mechanosensitive behavior arises from its multidomain architecture, where distinct structural elements respond at different force scales.
Diagnostic dilemma: Doctors couldn't explain why a boy was bleeding from his eyes, ears and nose
Diagnostic dilemma: Doctors couldn't explain why a boy was bleeding from his eyes, ears and nose A case of a boy who bled from his eyes eventually led doctors to a diagnosis that has been reported fewer than 50 times in the medical literature. The patient: An 11-year-old boy in India The symptoms: The boy's parents brought him to a hospital after he had several episodes of bleeding from his eyes, nose and ears. The episodes, which had occurred for about a month, seemed to start for no...