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Related Articles from SNS
Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.
Wnt signalling is a conserved pathway that orchestrates key developmental processes by regulating cell fate, proliferation, and tissue organisation. While the production and secretion of Wnt ligands are well characterised, less is known about how lipid-modified Wnts are delivered for long-range communication. Recently, cytonemes - actin-based signalling filopodia - have been identified as transporters of Wnts over distances to target specific cells in embryogenesis.
Hierarchical Forecast Reconciliation for Urban Rail Transit Demand Prediction under Operational Disruptions
Announce Type: new Abstract: Accurate and coherent passenger demand forecasting is essential for Urban Rail Transit (URT) operations. Passenger demand has a hierarchical structure in which origin-destination (OD) flows aggregate to station-level inflows and outflows through conservation constraints. In practice, station-level and OD-level forecasts are often generated independently, producing incoherent predictions that violate these constraints and introduce inconsistencies into operational...