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Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis.
Wnt signalling is a conserved pathway that orchestrates key developmental processes by regulating cell fate, proliferation, and tissue organisation. While the production and secretion of Wnt ligands are well characterised, less is known about how lipid-modified Wnts are delivered for long-range communication. Recently, cytonemes - actin-based signalling filopodia - have been identified as transporters of Wnts over distances to target specific cells in embryogenesis.
Netrin-1 drives cell-type-specific plasticity of human dopaminergic neurons during circuit integration in a Parkinsonian model
The survival of transplanted ventral midbrain (vm) dopaminergic neurons (DAn) and their innervation of host striatal tissue are crucial for ameliorating motor symptoms in Parkinson`s disease (PD). However, human pluripotent stem cells (hPSC) show inferior axonal plasticity compared to fetal donor tissue. While modulation of the host environment with trophic cues, such as glial cell-derived neurotrophic factor (GDNF), can improve graft outcomes, these cues lack specificity for DAn, resulting...
Transcriptomic profiling of the human habenula reveals a shared molecular architecture across mood disorders
The habenula is a critical regulator of monoaminergic and reward circuitry and is increasingly implicated in the neurobiology of mood disorders. Preclinical studies demonstrate that habenula hyperactivity drives depressive-like behaviours and can be reversed by interventions such as ketamine and deep brain stimulation. However, the molecular architecture of the human habenula remains largely unexplored.
Ancient Chinese medicine could transform hair loss treatment
Ancient Chinese medicine could transform hair loss treatment - Date: - June 7, 2026 - Source: - KeAi Communications Co., Ltd. - Summary: - A traditional Chinese medicinal root used for over a thousand years is attracting new scientific attention for its potential to combat hair loss. Studies suggest Polygonum multiflorum can block harmful hormones, activate hair-growth signals, protect follicles, and boost blood flow to the scalp. Researchers say the herb’s effects align remarkably well with...
Proteomic analysis of human leptomeningeal matrisome identifies changes in Alzheimer's disease
The leptomeninges (arachnoid and pia) are the inner layers of the meninges that envelope the brain. They define the borders of the subarachnoid space (SAS) where cerebrospinal fluid (CSF) circulates. Leptomeninges act as the barrier tissue and contribute to fluid exchange and immune function of the brain.
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer
Background Transcriptional regulation is shaped by both genomic variants and the environment. Yet, how the regulatory effects of genomic variants are reconfigured by dynamic epigenomic changes during tumorigenesis remains incompletely understood. Methods We investigated methylation context-dependent links between genotype and gene expression in colorectal cancer (CRC) using paired tumor and normal-adjacent tissue (NAT) from 80 patients, thereby controlling for germline genomic background.
Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia
Schizophrenia (SCZ) is a severe and debilitating neurodevelopmental disorder with lifelong impact on everyday life. Disruptions in synapse functions play a key role in its complex and poorly understood etiological and pathological mechanisms. Here, we investigated both the molecular composition and the spontaneous and stimulated functional properties of synapses in neural organoids from SCZ individuals.