Xenopus
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Related Articles from SNS
The XenCart Protocol: A Method for Alcian Blue Labeling and Quantitative Analysis of Craniofacial Cartilage in Xenopus
Craniofacial birth defects, such as cleft lip and palate, are among the most common congenital anomalies and often arise from disruptions in early facial patterning. Many of these defects are linked to environmental teratogens, yet such exposures cannot be directly tested in humans, making animal models essential for evaluating developmental risks. Xenopus laevis offers a powerful solution: its tadpoles develop externally, share deeply conserved craniofacial patterning mechanisms with...
Ultra-Slow Rhythmic Movement in the Elongating Tail of Xenopus Tadpoles
Since Darwin's time, ultra-slow oscillatory movements have been recognized as a characteristic feature of axis elongation in plant organs such as shoots and tendrils, yet have not been reported in elongating animal body axes. Here, using long-term imaging of multiple anesthetized Xenopus laevis embryos with a modified document scanner, we identify a previously unrecognized ultra-slow rhythmic movement in the developing tadpole tail. This movement emerged during tailbud development, persisted...
Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions
Multicellular vertices are important cellular interfaces for mediating tissue dynamics across the epithelium. Here, we report that expression of the vertebrate adhesion protein, Sidekick2 (Sdk2), localizes to vertebrate multicellular adherens junctions in the embryonic Xenopus laevis epithelium. Using the developmental process of radial intercalation, we find Sdk2 facilitates multiciliated cell penetrance into the outer epithelium at multicellular junctions.