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Multi-kilohertz laser plasma acceleration driven by an industrial-grade Yb:YAG laser

new Abstract: Laser plasma accelerators (LPAs) are a promising platform for compact radiation sources. For a wide range of applications, including radiotherapy, ultrafast electron diffraction and time-resolved imaging, stable operation at high repetition rates is essential in order to deliver competitive average particle flux. Here we demonstrate the first LPA driven by an industrial-grade ytterbium-doped yttrium aluminium garnet (Yb:YAG) laser, designed for high-average-power operation.

arXiv Physics 2d ago

DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma

Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to conventional chemotherapy. To date the molecular mechanisms underlying multidrug resistance remain poorly defined. Here, we integrate single-cell transcriptomics, clinicopathological analysis, and functional genomics to elucidate the molecular basis of cisplatin resistance in iCCA.

bioRxiv 3d ago

A Dual Metastable-State Encoding Architecture for Quantum Processing with $^{171}\mathrm{Yb}$ Atom Arrays

arXiv:2606.08453v1 Announce Type: cross Abstract: Neutral-atom arrays combine scalable qubit registers, long coherence times, flexible optical control, and strong Rydberg-mediated entangling interactions, making them a promising platform for quantum information processing. However, physical error rates remain a challenge, and fault-tolerant quantum error correction (QEC) requires repeated mid-circuit measurement and reset of ancilla qubits without disturbing nearby data qubits. This...

arXiv Physics 1d ago

A framework for continuous superradiant laser operation via sequential transport of atoms

arXiv:2509.07833v3 Announce Type: replace Abstract: We perform a theoretical study of a continuous superradiant laser supporting its experimental realization at FEMTO-ST using two sequentially-emitting ensembles of ${}^{171}\mathrm{Yb}$ atoms coupled to the same Fabry-Perot cavity. Using an open quantum system approach, we identify for the simplest case the parameter space where the laser reaches tens of picowatts of power with a sub-millihertz linewidth. Studying the impact of inhomogeneous...

arXiv Physics 5d ago

Passive all-optical synchronization for polarization-maintaining ultrafast fiber lasers

arXiv:2606.06799v1 Announce Type: new Abstract: We have proposed and implemented for the first time to our best knowledge a passive and all-optical pulse synchronization for polarization-maintaining ultrafast fiber lasers. Specifically, the synchronization system was comprised of two independent Yb-doped and Er-doped mode-locked fiber lasers in a master-slave configuration. Master pulses were injected into the slave laser cavity consisting of a nonlinear amplifying loop mirror, which...

arXiv Physics 2d ago

Suppression of differential light shifts in ground and metastable trapped-ion qubits

arXiv:2606.02543v1 Announce Type: new Abstract: In the presence of a magnetic field, hyperfine clock qubits can acquire a vector differential light shift that can be tuned via polarization to suppress the total differential light shift of high-power, off-resonant laser light. We experimentally measure this "magic" polarization condition, suppressing differential light shifts in both the ${}^2\mathrm{S}_{1/2}$ ground and ${}^2\mathrm{F}_{7/2}^o$ metastable clock qubits of...

arXiv Physics 8d ago

A thorium-229 optical nuclear clock with feedback loop

Announce Type: replace Abstract: The laser-accessible nuclear transition in the thorium-229 isotope has been identified as a promising candidate for the realization of an optical nuclear clock. Such a nuclear clock might rival or outperform current optical clocks based on electron-shell transitions in atoms or ions, is expected to be more robust against external perturbations, and provides enhanced sensitivity in clock-based tests of fundamental principles of physics. Here, we implement a...

arXiv Physics 2d ago

Fast single-atom preparation in optical tweezers via Rydberg blockade

arXiv:2606.03922v1 Announce Type: new Abstract: Continuously replenished optical tweezer arrays will unlock unlimited-depth quantum circuits with neutral atom qubits. A key bottleneck limiting the cycle time of these systems is removing atoms from tweezers initially loaded with more than one atom. In the conventional technique of light-assisted collisions, slow collisional dynamics limit the timescale for removing excess atoms to several milliseconds.

arXiv Physics 7d ago

Analysis of multi-pass pumped thin-disk laser performance with measured disk deformation

arXiv:2512.05771v3 Announce Type: replace Abstract: Predicting the steady-state performance of high-power thin-disk lasers requires not only pump-signal energy transfer but also how disk deformation contributes intra-cavity mode formation. In this work, we address the output-power reduction that occurs even when the laser remains in a single-mode regime with $\mathrm{M^2}$ around 1.1.

arXiv Physics 9d ago

A thorium-229 optical nuclear clock with feedback loop

Announce Type: new Abstract: The laser-accessible nuclear transition in the thorium-229 isotope has been identified as a promising candidate for the realization of an optical nuclear clock. Such a nuclear clock might rival or outperform current optical clocks based on electron-shell transitions in atoms or ions, is expected to be more robust against external perturbations, and provides enhanced sensitivity in clock-based tests of fundamental principles of physics. Here, we implement a...

arXiv Physics 6d ago