Your Spatial Foundation Model
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Related Articles from SNS
SpatialBench: Is Your Spatial Foundation Model an All-Round Player?
arXiv:2605.27367v2 Announce Type: replace Abstract: While spatial foundation models have demonstrated impressive performance on standard datasets, a critical question remains: are they truly all-round players capable of generalizing robustly across diverse downstream tasks, arbitrary viewpoints, shifting scene domains, varying input densities, and specific hardware constraints? Answering this overarching question requires a holistic assessment, yet current models are mainly evaluated on...
AlloSpatial: Agentic Harness Framework for Spatial Reasoning in Foundation Models
arXiv:2606.08952v1 Announce Type: new Abstract: Multimodal Foundation Models (MFMs) have made substantial progress, yet remain fragile in spatial reasoning over the physical world. A key bottleneck lies in their inability to transform local egocentric observations into a global allocentric spatial representation. To address this, we propose AlloSpatial, an agentic framework for allocentric spatial cognition in foundation models.
SciCore-Omics: a tri-modal foundation model unifying histology, spatial transcriptomics and language for spatial biology
Histomorphology and spatial transcriptomics capture complementary aspects of tissue biology, but their relationships remain difficult to extract, align, and interpret at scale. Existing foundation models typically connect histology, omics, or language only pairwise, which limits their capacity to jointly infer molecular states, decode spatial tissue organization, and generate biologically grounded explanations. Here, we show SciCore-Omics, the first tri-modal foundation model linking...
HEIST: A Graph Foundation Model for Spatial Transcriptomics and Proteomics Data
arXiv:2506.11152v4 Announce Type: replace-cross Abstract: Single-cell transcriptomics and proteomics have become a great source for data-driven insights into biology, enabling the use of advanced deep learning methods to understand cellular heterogeneity and gene expression at the single-cell level. With the advent of spatial-omics data, we have the promise of characterizing cells within their tissue context as it provides both spatial coordinates and intra-cellular transcriptional or...
FMplex: Model Virtualization for Serving Extensible Foundation Models
arXiv:2606.09643v1 Announce Type: new Abstract: Foundation models (FMs) are increasingly used as backbones for downstream tasks across language, vision, time-series, and multimodal applications. Yet existing model-serving systems deploy each customized task as an independent model instance, thereby replicating heavyweight backbones, wasting accelerator memory, and losing opportunities to amortize batching and loading costs. This paper presents FMplex, a serving system that treats FM...
Do Foundation Models See Biology? Evaluating Attention Coherence with Spatial Transcriptomics in Glioblastoma
Announce Type: new Abstract: Whether attention maps from pathology foundation models capture genuine biology remains unknown, yet this question is critical for clinical trust and regulatory approval. We propose a spatial transcriptomics-based framework for orthogonal, hypothesis-free evaluation of attention and apply it to five pathology foundation models (CONCH v1.5, UNI v2, Virchow2, GigaPath, H-Optimus-1) and a ResNet50 baseline. Using attention-based multiple instance learning, we train...
A Graph Foundation Model with Spectral Parsing and Prototype-Guided Spatial Propagation
Announce Type: new Abstract: Graph foundation models aim to learn transferable knowledge from diverse graphs for generalization to unseen graphs and tasks. Unlike text and images, graphs lack a shared vocabulary or regular spatial grid, making cross-graph transfer challenging. This challenge comes from both feature discrepancies and, more critically, diverse graph structures.
Where to Look: Can Foundation Models Reach a Target Viewpoint Through Active Exploration?
Announce Type: new Abstract: Humans can reproduce the viewpoint specified by a target image through active head and body motion, yet spatial intelligence in foundation models has largely been studied as passive understanding of pre-collected observations. We introduce Target Viewpoint Reproduction (TVR) -- an active task where an agent adjusts its viewpoint in a 3D environment until its observation matches a given target image -- and TVRBench, an indoor-simulation benchmark spanning scene...
Single-Cell Cross-Modal Transfer by Adversarial Fine-Tuning of Foundation Models
Announce Type: cross Abstract: Spatial transcriptomics (ST) is a powerful tool for exploring biological properties dependent on structure, proximity, and interaction in tissue. The methods underpinning ST are developing rapidly but are limited in their ability to profile many thousands of genes at a subcellular scale. Although dissociated from tissue, it is known that the whole-transcriptome readouts of cells in single-cell RNA sequencing (scRNA-seq) retain information about their former in...
Spatial Transcriptomics-Guided Alignment Enhances Molecular Profiling in Pathology Foundation Model
Announce Type: new Abstract: Comprehensive molecular profiling is essential for modern precision oncology but remains hindered by prohibitive costs, specimen exhaustion, and protracted turnaround times. While pathology foundation models (PFMs) have demonstrated potential for inferring molecular phenotypes from routine hematoxylin and eosin (H&E) whole-slide images (WSIs), current architectures primarily rely on vision-centric self-supervised learning or vision-language alignment, lacking...