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Related Articles from SNS
A new strategy for assembling π-conjugated panels into square molecules revealed
A new strategy for assembling π-conjugated panels into square molecules revealed Gaby Clark Scientific Editor Alexander Pol Deputy Editor A research group has developed a new method for selectively synthesizing three-dimensional macrocycles,⁽¹⁾ in which four panels are arranged in a square, by connecting planar π-conjugated molecules⁽²⁾ at right angles. This method is applicable to a wide variety of π-conjugated molecules and allows the size of the internal cavity to be designed....
Dynamic nanogates let longer molecules pass faster through flexible pores
Dynamic nanogates let longer molecules pass faster through flexible pores Stephanie Baum Scientific Editor Robert Egan Associate Editor A research team led by Professor Shuichi Hiraoka at the University of Tokyo and Professor Masanori Tachikawa at Yokohama City University has quantitatively analyzed how molecules pass through dynamic nanoscale pores using self-assembled molecular "nanocubes" in water. The researchers discovered an unexpected phenomenon: For linear alkane molecules, longer...
Yeast experiments reveal an evolutionarily conserved backup route for making a molecule that's essential to life
Yeast experiments reveal an evolutionarily conserved backup route for making a molecule that's essential to life Lisa Lock Scientific Editor Robert Egan Associate Editor Hiroshima University researchers say a newly proposed three-step "detour" pathway for making dolichol, a molecule cells need to properly process proteins, may be more universal than scientists realized. Experiments in yeast suggest eukaryotes may rely on overlapping biochemical pathways, including the evolutionarily...
Non-destructive cavity readout of molecules for precision measurements
arXiv:2606.01743v1 Announce Type: new Abstract: We propose a non-destructive method to measure the population of molecules in a selected rotational-hyperfine state by coupling them to a high-finesse optical cavity. In contrast to traditional techniques, our approach enables fast (less than 1 ms) repeated measurements with reduced heating and losses, and with precision below the standard quantum limit. The method is particularly advantageous for radioactive molecules, systems of high interest...
Common plastics soak up ballistic impacts thanks to a cross-linking molecule
Common plastics soak up ballistic impacts thanks to a cross-linking molecule Sadie Harley Scientific Editor Robert Egan Associate Editor With help from a novel cross-linking molecule, MIT chemists have shown they can substantially improve the ballistic impact resistance of common polymers, including polystyrene and a type of rubber used to make shoe soles. Polystyrene is a hard, glassy polymer that is used to make many types of plastic containers, such as bottles and mugs, as well as...
Amazon rainforest emits new stress-defense molecules during El Niño drought
Amazon rainforest emits new stress-defense molecules during El Niño drought Gaby Clark Scientific Editor Robert Egan Associate Editor The Amazon rainforest responded to the most severe drought ever recorded in the basin with an unexpected defense mechanism. Researchers at the Max Planck Institute for Chemistry in Mainz, Germany, found that during and after the intense 2023–2024 El Niño cycle, the most intense drought ever recorded in the region, vegetation significantly changed its chemical...
Creating and Probing Spin-Squeezed States of Molecules
Announce Type: new Abstract: Polar molecules are a promising platform for quantum-enhanced sensing and precision tests of fundamental physics, owing to their strong long-range dipolar interactions, broad sensitivity to electromagnetic fields, and sensitivity to potential physics beyond the Standard Model. However, the creation of metrologically useful entangled states in molecular systems has remained elusive. Here, we report the first observation of a class of metrologically useful...
Reconfigurable Single-Ring Photonic Molecule on Lithium Niobate
arXiv:2606.06637v1 Announce Type: new Abstract: Resonant photonic structures enable optical enhancement and spectral filtering and are essential for lasers, quantum emitters, transducers, or modulators. Photonic molecules, formed by mode hybridisation in two coupled resonators, break the equidistant frequency spacing of zero-dispersion resonators and provide control over their spectrum. Reconfigurability over these devices is a key asset, allowing to align photonic resonances to target...
Active Flow Expansion for Out-of-Distribution Discovery: from Theory to Molecules
arXiv:2606.08802v1 Announce Type: new Abstract: Standard flow and diffusion pre-training matches the distribution of available data (e.g., molecules), which often covers only a small fraction of the valid design space. In generative discovery, however, one aims to sample valid new-to-nature designs, assigned negligible probability under, and thus inaccessible to, standard models fitted to the observed data.
An accurate nucleic acid-small molecule docking framework via geometric deep learning with large-scale pretraining
arXiv:2606.05198v1 Announce Type: cross Abstract: Nucleic acids are increasingly recognized as therapeutic targets beyond conventional protein-centered drug discovery, yet accurate and efficient docking of small molecules to nucleic acid structures remains challenging. Physics-based docking methods often show limited accuracy and efficiency, whereas deep learning approaches are constrained by the scarcity of experimentally resolved nucleic acid-ligand complexes. Here, we present NucleoDock,...