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Diverse binding poses of agonistic neurotoxins on human Na<sub>v</sub>1.6
Abstract Voltage-gated sodium (Nav) channels are key targets of various venomous toxins. Deciphering the binding poses and mechanisms of action of representative toxins will help to dissect the functional mechanism of the channels and facilitate therapeutic development targeting Nav channels1,2. Here we present cryo-electron microscopy (cryo-EM) structures of distinct binding poses of three agonistic peptide toxins on the human Nav1.6–β1 channel complex.
Generative AI-Enabled Refund Fraud in Chinese E-Commerce: Investigation on Merchants and Platform Workers
arXiv:2606.03215v1 Announce Type: new Abstract: E-commerce dispute resolution typically relies on the security assumption that digital evidence truthfully reflects physical reality. Generative AI (GenAI) invalidates this threat model, enabling attackers to fabricate hyper-realistic evidence of product defects at negligible cost. Through semi-structured interviews with merchants (N=17) and platform workers (N=13) in the Chinese e-commerce market, we characterize this shift toward...
Large Language Lovers: Lived Experiences of Negotiating Agency and Platform Control in AI Companionship
Announce Type: replace Abstract: Individuals are turning to increasingly anthropomorphic, general-purpose chatbots for AI companionship, rather than roleplay-specific platforms. However, not much is known about how individuals perceive and conduct their relationships with general-purpose chatbots. We triangulated community discussions on Reddit (41k+ posts and comments), survey responses (n=43), and semi-structured interviews (n=13) which revealed internal dynamics, external influences, and...
Finite-n Estimate of Dedekind Numbers by Layer-Ratio Monte Carlo
Announce Type: cross Abstract: Dedekind's problem counts monotone Boolean functions, equivalently downsets of a Boolean lattice. We recast this enumeration as a finite layer-ratio reconstruction problem for the Whitney numbers of the ranked ideal lattice. An exact adjacent-layer double count expresses each layer ratio through local averages of the number of addable elements and the number of removable elements.
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Quantitative Movement Testing: Measuring Patient Movements from a Single Smartphone Video
arXiv:2606.02301v1 Announce Type: new Abstract: Chronic pain diminishes quality of life by decreasing functional ability, yet objectively measuring this functional impact remains challenging in real-world settings. While optical motion capture provides high precision for assessing altered movement quality, it is costly and restricted to laboratory environments. We aimed to develop and validate Quantitative Movement Testing (QMT), a computer vision pipeline extracting 3D kinematic biomarkers...
Reframing preprocessing selection as model-internal calibration in near-infrared spectroscopy: A large-scale benchmark of operator-adaptive PLS and Ridge models
arXiv:2605.13587v3 Announce Type: replace-cross Abstract: Preprocessing screening is often the most expensive part of a near-infrared spectroscopy calibration workflow. It works because smoothing, derivatives, detrending and related filters change the spectral directions seen by partial least squares (PLS) or Ridge regression, but a full external search repeatedly refits nearly the same linear model.
The Cross-Architecture Substrate: A Domain-Transcendent, Calibration-Surviving Geometric Invariant of Modern Vision Encoders
arXiv:2606.07882v1 Announce Type: new Abstract: Different vision neural networks -- trained to classify, contrast, reconstruct, or match images to text -- should have correspondingly different internal representations. We report that they do not.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).