optogenetic LC

Locus coeruleus activation transforms cortical taste representations

Norepinephrine neurons in the locus coeruleus (LC) shape sensory responses across the brain, yet how LC activity reorganizes population representations of behaviorally relevant sensory attributes remains unclear. We addressed this question in the primary gustatory cortex (GC), a system largely unexplored in neuromodulation research and well-suited for linking sensory coding to affective value. Using miniscope calcium imaging in awake mice combined with optogenetic LC activation, we tested...