pangenome assembly
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In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it Scientists have uploaded a viral genome to a quantum computer, marking an important step for the future of quantum-enabled advancements in biology. Scientists say they have uploaded a real genome to a quantum computer for the first time, marking an important step in applying the emerging technology to biology. The researchers encoded the entire genome of the hepatitis D virus (HDV) onto a...
A Pan-pangenome illuminates complex structural variation and selection in humans, chimpanzees, and bonobos
Complete, haplotype-resolved genome assemblies have provided unprecedented insight into the evolution of structurally complex, rapidly evolving regions of human genomes; however, population-scale pangenome resources of our closest relatives, chimpanzees and bonobos (genus, Pan), are necessary to ascertain the origins and evolutionary context of these loci. Here, we sequence and assemble 58 haplotypes from four distinct Pan clades to high contiguity (median contig NG50=54 Mb), including eight...
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.