paralog Nir1
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Related Articles from SNS
Nir1-Nir2 Heterodimerization Confers Robustness to the Phosphoinositide Cycle
The phosphatidylinositol (PI) cycle maintains plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) levels to sustain signaling and cellular homeostasis in receptor-stimulated cells. This process requires recruitment of the PI transfer protein Nir2 to endoplasmic reticulum (ER)-PM junctions where PI and phosphatidic acid are exchanged between the two membranes. Nir2 recruitment is promoted by its paralog Nir1, which lacks PI transfer activity but is constitutively localized to...