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SleepVLM: Explainable and Rule-Grounded Sleep Staging via a Vision-Language Model
Announce Type: replace Abstract: While automated sleep staging has achieved expert-level accuracy, its clinical adoption is hindered by a lack of auditable reasoning. We introduce SleepVLM, a rule-grounded vision-language model (VLM) that stages sleep from multi-channel polysomnography (PSG) waveform images and generates clinician-readable rationales based on American Academy of Sleep Medicine (AASM) scoring criteria. Utilizing waveform-perceptual pre-training and rule-grounded supervised...
The hypertrophic cardiomyopathy mutation G768R makes cardiac myosin a high duty ratio motor
{beta}-cardiac myosin is the primary motor protein in the human heart responsible for force generation by converting chemical energy from ATP hydrolysis to mechanical work. It binds actin, produces force through its powerstroke, and releases actin, and must complete this cycle several times a second within each heartbeat. Like other muscle myosins, cardiac myosin has a low duty ratio of ~5%, the fraction of time in the actin-bound force-producing state.