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Spatially resolved mapping of tau amplification rates via differentiable simulation of prion-like propagation
Neurodegenerative diseases exhibit characteristic yet heterogeneous patterns of pathological spread, whose underlying determinants remain unclear. A central challenge is that inferring spatially heterogeneous propagation kinetics from neuroimaging data constitutes a high-dimensional inverse problem that has remained intractable at whole-brain scale. Here we present a differentiable reaction-diffusion framework that enables inference of spatially resolved tau amplification rates directly from...
SC-TauPath: A Structural Connectivity Attribution Framework for Mapping Tau Propagation Pathways in Alzheimer's Disease
arXiv:2606.04066v1 Announce Type: cross Abstract: Understanding how structural connections are associated with tau propagation in Alzheimer's disease (AD) remains a central open question, yet existing computational models either rely heavily on biophysical assumptions or lack neurobiologically interpretable pathway maps. We present SC-TauPath, a structural connectivity (SC) attribution framework that maps tau propagation pathways from in vivo neuroimaging data. SC-TauPath combines a Network...