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Navigating the unknown in large-scale operational transformation programs: The "Sirius Days" framework as a 'pilot-organization' for characterizing emerging issues
new Abstract: Large-scale digital transformation programs must simultaneously sustain existing operations and navigate deep unknowns emerging from IT-business-operations interactions -a challenge conventional project governance frameworks inadequately address. Based on a longitudinal case study of a transformation program, we investigate the ''Sirius Days,'' a monthly senior management retreat identified as a critical success factor. We show that this framework constitutes a...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
The Last Evolution, by John W Campbell Jr. (1932)
The Project Gutenberg EBook of The Last Evolution, by John Wood Campbell This eBook is for the use of anyone anywhere at no cost and with almost no restrictions whatsoever. You may copy it, give it away or re-use it under the terms of the Project Gutenberg License included with this eBook or online at www.gutenberg.org
Is Trump really a Knicks fan? History doesn’t put him in pantheon of Ben Stiller, Spike Lee and Timothée Chalamet
Is Trump really a Knicks fan? History doesn’t put him in pantheon of Ben Stiller, Spike Lee and Timothée Chalamet An unpopular president returns to inconvenience a city that rejected him to watch a team that he never much cared for, writes Andrew Feinberg — just so he can be seen - Bookmark - CommentsGo to comments If there’s one thing that can be said about Donald Trump, it’s that he’s a sports fan. From his earliest days on the campaign trail in 2015, Trump and his aides spun yarns about...
Paul McCartney at 83, still trying to do it all – with a touching album echoing his celebrated career
On his musical memoir about growing up in Liverpool, Paul McCartney sings:"My father was a salesman"My mother was a saint"Working every God-given minute"To make enough to pay the rent."'PAUL MCCARTNEY REVEALS HOW A 'HAPPY' TEEN HITCHHIKING TRIP WITH GEORGE HARRISON DELIVERED A SHOCKOf course, she’s a saint – remember "Mother Mary comes to me," from Let It Be – and McCartney is not quite in that category. But in the lead-up to his 84th birthday, more than half a century after his band broke...
What A.J. Brown would bring to the Patriots' offen...
FOXBOROUGH, Mass. -- Quick-hit thoughts and notes around the New England Patriots and NFL: 1. Eyes on A.J.: When Patriots receivers went through drills in practice last Wednesday, fourth-year pro DeMario "Pop" Douglas always took the first repetition. Will that be A.J. Brown this week?