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Related Articles from SNS
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer
Background Transcriptional regulation is shaped by both genomic variants and the environment. Yet, how the regulatory effects of genomic variants are reconfigured by dynamic epigenomic changes during tumorigenesis remains incompletely understood. Methods We investigated methylation context-dependent links between genotype and gene expression in colorectal cancer (CRC) using paired tumor and normal-adjacent tissue (NAT) from 80 patients, thereby controlling for germline genomic background.
Structure-Aware Prediction of PROTAC-Mediated Protein Degradability via Graph Neural Networks
Announce Type: cross Abstract: Proteolysis-targeting chimeras (PROTACs) can selectively degrade disease-causing proteins, yet predicting which targets are amenable to degradation remains a critical bottleneck: existing computational methods require the complete PROTAC molecular structure, information unavailable before synthesis. We present DegradoMap, a graph neural network that predicts PROTAC-mediated degradability from protein structure and E3 ligase identity alone -- the minimal...
Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Davina McCall opens up on ‘liberating’ discussion with Princess Kate as pair share cancer experiences
Davina McCall opens up on ‘liberating’ discussion with Princess Kate as pair share cancer experiences The broadcaster was diagnosed with breast cancer in October last year but said in April she had now received the “all clear” following surgery - Bookmark - CommentsGo to comments The Princess of Wales and TV presenter Davina McCall have talked about their experiences of cancer at a reception marking the 125th anniversary of a charity. The King, who is patron of Cancer Research UK, hosted the...
New 3D microscope technology captures high-resolution tissue images at a fraction of the cost
New 3D microscope technology captures high-resolution tissue images at a fraction of the cost Sadie Harley Scientific Editor Robert Egan Associate Editor A team led by Raju Tomer, professor of biological sciences at Columbia University, has created a new design for microscopes and microscope lenses that could push 3D tissue imaging beyond state-of-the-art systems while drastically cutting costs and complexity. Details of the design were published in the journal Nature Biotechnology. Modern...
Predicting the risk of colorectal anastomotic leak based on preoperative mapping of the blood supply of the bowel
arXiv:2606.02156v1 Announce Type: cross Abstract: Anastomotic leak remains one of the most serious complications following colorectal cancer surgery, substantially affecting patient outcomes, recovery trajectories, and healthcare costs. Despite advances in imaging technology, current preoperative assessment relies only on clinical assessment, a process that is subjective, error-prone, and highly dependent on individual expertise.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
Greenland shark genome reveals clues to 400-year lifespan
June 3, 2026 report Greenland shark genome reveals clues to 400-year lifespan Paul Arnold Author Gaby Clark Scientific Editor Robert Egan Associate Editor The first comprehensive map of nearly the entire Greenland shark genome is beginning to reveal some of the genetic clues behind its incredibly long life. The work could one day help scientists develop new cures and treatments for cancer and other age-related diseases. Greenland sharks (Somniosus microcephalus) are incredible animals.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...