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Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer
Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.
Scientists shut down cancer DNA repair to overcome drug resistance
Scientists shut down cancer DNA repair to overcome drug resistance Researchers found a way to pull the plug on cancer’s DNA repair system, potentially making resistant tumors treatable again. - Date: - June 10, 2026 - Source: - Institute for Basic Science - Summary: - Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause.
SIRT7 regulates dosage compensation and safeguards the female X chromosome
Abstract Sirtuins are deacetylases implicated in stress responses and longevity in mammals1,2. Although their differential impact on disease for the two sexes has been noted3,4,5,6,7, the underlying reasons are unclear. Here, using Sirt7 as a model in mice, we examine the mechanisms leading to sex differences and find that Sirt7−/− female mice have decreased fitness throughout their lifespan.
Lignin to adipic acid in a high-yield chemical and biological redox process
Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...
Scientists discover inherited traits that break Mendel’s Laws of genetics
Scientists discover inherited traits that break Mendel’s Laws of genetics - Date: - June 1, 2026 - Source: - Johns Hopkins Medicine - Summary: - A major mouse study found that some inherited traits are passed down through epigenetic changes that break the classic rules of genetics. Researchers discovered hundreds of cases where these chemical DNA marks behaved unexpectedly, including some that seemed to emerge out of nowhere. They also identified the first known naturally occurring...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
How honeybees really crown their queens
How honeybees really crown their queens Sadie Harley Scientific Editor Robert Egan Associate Editor For generations, scientists believed a queen honeybee was made almost entirely by diet: feed an ordinary larva enough royal jelly and a ruler emerges. But new research suggests queens are created through a more elaborate process. Young worker bees construct specialized nursery chambers complete with custom wax, warmer temperatures, and devoted attendants that help determine whether a larva...
Integrating citizen science with experimental data uncovers how switchgrass adapts flowering by region
Integrating citizen science with experimental data uncovers how switchgrass adapts flowering by region Gaby Clark Scientific Editor Robert Egan Associate Editor In its native habitat, switchgrass flowered earlier when growing farther north. In experiments with diverse genetic samples, it flowered earlier in the south. The discrepancy wasn't a welcome sight for a research team studying how prairie grasses respond in different environments, but resolving the apparent conflict led the...
RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route
RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route Gaby Clark Scientific Editor Robert Egan Associate Editor IS110 transposons are a large, diverse family of bacterial insertion sequences (IS elements)—small, mobile DNA elements that can move from one genomic location to another. They have recently attracted broad interest due to the finding that some of these transposons use a bridge RNA (bRNA) to recognize both donor DNA and target DNA. Upon...
Data gaps of international databases on HPAI H5 in wildlife in the Americas: implications for surveillance, research, and conservation
Global efforts to prevent and mitigate the impacts of high pathogenicity avian influenza (HPAI) H5 on domestic animals, humans, and wildlife rely on timely and transparent information that is both accurate and interpretable across countries and sectors. International epidemiological and genomic databases, such as the World Animal Health Information System (WAHIS), the Global Animal Disease Information System (EMPRES-i+), the Global Initiative on Sharing All Influenza Data (GISAID), and the...