Home Knowledge Base the Chinese Academy of Medical Sciences

the Chinese Academy of Medical Sciences

No mentions found

This entity hasn't been tracked yet, or Iris is still building its knowledge base.

Related Articles from SNS

RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route

RNA-guided transposon mechanics show use of figure-eight intermediate and direct-transfer route Gaby Clark Scientific Editor Robert Egan Associate Editor IS110 transposons are a large, diverse family of bacterial insertion sequences (IS elements)—small, mobile DNA elements that can move from one genomic location to another. They have recently attracted broad interest due to the finding that some of these transposons use a bridge RNA (bRNA) to recognize both donor DNA and target DNA. Upon...

Phys.org 5d ago

Wounds may trigger 'aged' cells within hours, reshaping how senescence starts

Wounds may trigger 'aged' cells within hours, reshaping how senescence starts Sadie Harley Scientific Editor Robert Egan Associate Editor What if a process we associate with aging actually helps the body heal? A study led by Mikolaj Ogrodnik, LBI Trauma, published in Nature Cell Biology, shows that cells enter a state of senescence within minutes to hours after an injury—and that this rapid response not only plays a key role in wound healing, but also changes the paradigm of how slowly...

Phys.org 8d ago

Molecular glue degraders of HuR suppress BRAF-mutant colorectal cancer

Abstract BRAF gain-of-function mutations, particularly BRAF(V600E), affect roughly 10% of all patients with colorectal cancer (CRC), and portend poor prognosis with limited therapeutic interventions. BRAF inhibitors such as encorafenib are ineffective due to MAPK pathway reactivation driven by BRAF dimerization. Combined inhibition of BRAF and EGFR, although approved therapies, results in short survival benefits and frequent treatment resistance and relapse1,2,3.

Nature 17h ago