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A functional amyloid scaffold shapes insect egg coats

Functional amyloids serve as structural scaffolds across biology, yet the molecular architecture and assembly principles of many remain unresolved. The lepidopteran egg coat, or chorion, presents a striking example: hundreds of paralogous proteins sharing a conserved central domain assemble into a mechanically resilient amyloid matrix essential for embryo protection. Here, combining evolutionary analysis of more than 500 sequences with cryo-electron microscopy and biophysical assays, we...

bioRxiv 8d ago

Kindlin-1 loss disrupts vascular and extracellular matrix organisation to sustain hypoxia in cutaneous squamous cell carcinoma

Kindlin-1, encoded by FERMT1, is an essential integrin co-activator that regulates cell extracellular matrix (ECM) adhesion, tissue architecture, and microenvironment signalling. Loss-of-function mutations in FERMT1 cause Kindler epidermolysis bullosa, which is strongly associated with aggressive cutaneous squamous cell carcinoma (cSCC). Although Kindlin-1 deficiency promotes hypoxia and invasion, the impacts on ECM-vascular organisation and oxygen homeostasis are not known.

bioRxiv 7d ago

Relational Epipolar Graphs for Robust Relative Camera Pose Estimation

Announce Type: replace Abstract: A key component of Visual Simultaneous Localization and Mapping (VSLAM) is estimating relative camera poses using matched keypoints. Accurate estimation is challenged by noisy correspondences. Classical methods rely on stochastic hypothesis sampling and iterative estimation, while learning-based methods often lack explicit geometric structure.

arXiv CS 1d ago

Structure and Construction of Two-Dimensional Minimal Linear Codes over the rings $\mathbb{Z}_{p^n}$ with Applications to Secret Sharing

arXiv:2312.15954v3 Announce Type: replace Abstract: Minimal linear codes play an important role in coding theory and cryptography, particularly in the construction of secret sharing schemes. In this paper, we investigate the structure and construction of two-dimensional minimal linear codes over the finite rings $\mathbb{Z}_{p^n}$. We provide an explicit construction of a family of two-dimensional linear codes generated by a structured $2\times m$ matrix over $\mathbb{Z}_{p^n}$ and prove...

arXiv CS 2d ago

DynMuon: A Dynamic Spectral Shaping View of Muon

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arXiv CS 8d ago

How we index images for RAG

How we index images for RAG Reading the screenshots, diagrams and tables in technical documentation for LLMs by Matteo Bortoletto Kapa builds AI assistants that answer questions from technical documentation. The knowledge bases we process hold millions of images: screenshots, architecture diagrams, circuit schematics, annotated UI walkthroughs. We spent several months working out how to make them useful in our RAG pipeline.

Hacker News 7d ago

O-GlcNAc transferase regulates H2O2 production via p38 MAPK

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by augmented transforming growth factor-{beta} (TGF-{beta}) signaling leading to excessive extracellular matrix (ECM) deposition. The fibroblast-to-myofibroblast-transition (FMT) and metabolic reprogramming of lung fibroblasts (HLFs) are essential to IPF pathogenesis, yet the connection between nutrient metabolism and fibrogenesis remains poorly defined. The O-linked N-acetylglucosamine (O-GlcNAc)...

bioRxiv 10d ago

Breaking $1/\epsilon$ Barrier in Quantum Zero-Sum Games: Generalizing Metric Subregularity for Spectraplexes

arXiv:2509.21570v2 Announce Type: replace Abstract: Quantum zero-sum games provide a framework for non-local games, quantum interactive proofs, and quantum machine learning, where players optimize a bilinear payoff over quantum states. In contrast to classical bilinear games over polyhedral domains, for which gradient methods achieve linear last-iterate convergence, comparable guarantees over spectraplexes have remained open.

arXiv CS 6d ago

Making Graphics Like it's 1993

Personal website and blog. Catlantean 3D is a side-project I've been slowly building in my spare time for over a year, and I intend to release it on Steam next year. My goal was to build a complete, shippable first-person shooter using techniques that were common in the early 90s, while allowing myself the luxury of using a modern compiler and a platform abstraction layer.

Hacker News 1d ago

Spectral density estimation for normal matrices

Announce Type: new Abstract: The spectral density estimation problem asks for an algorithm that, given an $n\times n$ matrix $A$, outputs a probability measure that is a good approximation to the uniform distribution on the eigenvalues of $A$, called the spectral density of $A$. This paper considers the setting where $A$ is a large normal matrix that is accessible only through matrix-vector product queries. We provide an algorithm that makes just $m$ matrix-vector queries to $A$ and returns,...

arXiv CS 9d ago