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A prognostic human brain network for diffuse midline glioma

Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.

Nature 1d ago

Kernel Neural Operators (KNOs) for Scalable, Memory-efficient, Geometrically-flexible Operator Learning

Announce Type: replace Abstract: This paper introduces the Kernel Neural Operator (KNO), a provably convergent operator-learning architecture that utilizes compositions of deep kernel-based integral operators for function-space approximation of operators (maps from functions to functions). The KNO decouples the choice of kernel from the numerical integration scheme (quadrature), thereby naturally allowing for operator learning with explicitly-chosen trainable kernels on irregular geometries....

arXiv CS 6d ago

Functional Attention: From Pairwise Affinities to Functional Correspondences

arXiv:2605.31559v1 Announce Type: new Abstract: Learning mappings between infinite-dimensional function spaces, or operator learning, is essential for many machine learning applications. Although transformer-based operators are popular, they often rely on token-wise attention. These methods treat continuous fields as discrete tokens and usually ignore the global functional structure.

arXiv CS 9d ago

A Unified DeepONet Framework for Logarithmically Stable Infinite-Dimensional Inverse Problems

arXiv:2606.07122v1 Announce Type: new Abstract: We develop a unified DeepONet framework for logarithmically stable infinite-dimensional inverse problems, with inverse acoustic scattering as a model application. The framework is formulated at the operator level by separating the learned inverse map into measurement encoding, finite-dimensional neural approximation, and functional reconstruction components. For inverse maps satisfying a logarithmic stability estimate, we establish quantitative...

arXiv CS 2d ago

Neural Legendre-Fenchel transform with Hessian Preconditioning

Announce Type: new Abstract: The Legendre-Fenchel (LF) transform is a fundamental tool in convex analysis and machine learning that maps lower semi-continuous functions to their convex conjugates. In practice, when closed-form formula are not available for expressing convex conjugates of given functions, one must approximate them using various techniques. One recent such versatile numerical method is the deep Legendre transform method which relies on neural networks although it remains...

arXiv CS 1d ago

A density-functional perspective on force fields

Announce Type: replace Abstract: Force fields are usually formulated directly in nuclear configuration space, whereas density functional theory is naturally formulated in terms of external potentials, densities, and variational duality. We show that exact force fields are variationally induced by DFT: the Born-Oppenheimer potential-energy surface is the pullback of the external-potential energy functional along the map from nuclear configurations to Coulomb potentials.

arXiv Physics 1d ago

Speech Enhancement Based on Drifting Models

arXiv:2604.24199v4 Announce Type: replace Abstract: We propose Speech Enhancement based on Drifting Models (DriftSE), a novel generative framework that formulates denoising as an equilibrium problem. Rather than relying on iterative sampling, DriftSE natively achieves one-step inference by evolving the pushforward distribution of a mapping function to directly match the clean speech distribution. This evolution is driven by a Drifting Field, a learned correction vector that guides samples...

arXiv CS 1d ago

Reformulating Neural Operators in $d+1$ Dimensions for Embedding Evolution

arXiv:2505.11766v4 Announce Type: replace Abstract: Neural Operators (NOs) are powerful architectures for learning mappings between function spaces. While most advances focus on refining kernel parameterizations over the $d$-dimensional physical domain, the evolution of lifted embeddings remains underexplored, which often drives models toward computationally expensive embedding-scaling designs to improve approximation. In this paper, we introduce an auxiliary function dimension that models...

arXiv CS 5d ago

Fourier Neural Operators with rank-1 lattice points and hyperbolic cross

Announce Type: new Abstract: The \emph{Fourier neural operator} (FNO) is a neural network architecture that learns mappings between function spaces. Its efficient implementation is based on the multi-dimensional Fourier transform. By deriving general regularity bounds for the FNO with respect to both the spatial and parametric variables, we prove that the generalization error of the FNO can be improved by replacing spatial tensor product grids with purpose-built rank-1 lattice points, and by...

arXiv CS 1d ago

Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models

Mapping human brain function at high spatiotemporal resolution is constrained by the physical limitations of non-invasive imaging and the sparse sampling of invasive electrophysiology. While intracranial electroencephalography (iEEG) captures local field potentials with millimeter precision, clinical implantation strategies result in a ``coverage paradox'': observations are restricted to disjoint, patient-specific patches, leaving most of the cortex unobserved. This study introduces the...

bioRxiv 8d ago