the Functional Proximity Law
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Evidence for a Functional Proximity Law in Multilayer Networks
arXiv:2604.23639v3 Announce Type: replace Abstract: Hub importance scores in multilayer networks persist more strongly between functionally similar layers than dissimilar ones. We call this the Functional Proximity Law and test it across 31 pre-registered experiments: 13 canonical domains (10 confirmed, 3 denied; molecular biology, neuroscience, computer systems, ecology, linguistics, AI architecture) plus 18 pre-registered external and replication validations (15 confirmed, 1 denied, 2...
Topology as Logic: Structural Role Geometry Across Formal, Software, Biological, and Prebiotic Systems
Announce Type: new Abstract: We ask whether dependency topology correlates with functional load-bearing organization as recoverable geometry -- not as a metaphor, but as a measurable structural property detectable by multilayer network analysis. Across seven independent substrates, we show that hub persistence and rank divergence under the Functional Proximity Law recover operational organization that domain experts describe as logic: axiomatic load-bearing structure in formal mathematics,...
Proximal basin hopping: global optimization with guarantees
arXiv:2605.18364v2 Announce Type: replace Abstract: Global optimization is a challenging problem, with plenty of algorithms displaying empirical success, but scarce theoretical backing. In this work, we propose a new theoretical framework called Proximal Basin Hopping (PBH), carefully tailored to combine proximal optimization and local minimization. We use it to construct a practical algorithm that converges to the global minimizer with high probability, when using a finite amount of samples.
Structural basis for chaperone-guided assembly of RNA-induced silencing complex
Abstract The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process1,2,3, but the molecular mechanism remains poorly understood. Here we identify the human AGO–HSP90–p23 complex, which captures AGO in an RNA-free state, termed the AGO maturation complex (AMC).
US strikes Iran in response to helicopter shootdown
US strikes Iran in response to helicopter shootdown Published June 9, 2026last updated June 9, 2026What you need to know - US Central Command announces strikes on Iran after downing of US Apache helicopter over the Strait of Hormuz - Donald Trump had earlier threatened an attack on Iran over the helicopter shootdown - Israeli airstrikes hit Tyre in southern Lebanon after the military ordered the entire city to evacuate - Donald Trump says a Middle East peace deal is in the 'final throes' -...
US strikes Iran in response to Apache helicopter shootdown
US strikes Iran in response to helicopter shootdown Published June 9, 2026last updated June 9, 2026What you need to know - US Central Command announces strikes on Iran after downing of US Apache helicopter over the Strait of Hormuz - Donald Trump had earlier threatened an attack on Iran over the helicopter shootdown - Israeli airstrikes hit Tyre in southern Lebanon after the military ordered the entire city to evacuate - Donald Trump says a Middle East peace deal is in the 'final throes' -...