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An inflammatory gene set driven epigenetic clock tracks down disease progression and rejuvenation

Chronic, low-level inflammation, characterized by elevated pro-inflammatory programs, including epigenetic changes, in the absence of infection, is a major driver of aging and age-related diseases. On the other side of the spectrum, aging interventions work, at least in part, by decreasing inflammation. However, the molecular connection between epigenetic aging and inflammatory profiles in chronic diseases and rejuvenation has not been established yet.

bioRxiv 4d ago