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Study reveals hidden gut factor that may make some people more susceptible to sepsis
Potentially deadly sepsis may be more likely in certain patients due to problems in the gut. Researchers from the Korea Research Institute of Bioscience and Biotechnology's Infectious Disease Research Center used female mouse models to investigate why sepsis outcomes can vary so dramatically. The study, published in the journal Nature, looked at genetically similar mice with different gut microbiomes.
It blocked us at 'hello!' Anthropic Fable 5 refusing innocuous prompts
Anthropic's newly released Claude Fable 5 generative AI model is trying so hard to be safe that it's hurting its own userbase. Customers attempting to use the AI knowledge regurgitator are reporting that the model is refusing to answer harmless questions, an issue that has annoyed security researchers following past model releases. Anthropic warned that it had tuned Fable 5's guardrails conservatively: "they’ll sometimes catch harmless requests, though they trigger, on average, in less than...
Scientists found the hidden switch fueling alzheimer’s brain inflammation
Scientists found the hidden switch fueling alzheimer’s brain inflammation Scientists may have found a hidden Alzheimer’s “inflammation switch”—and turning it off protected brain connections in early studies. - Date: - May 31, 2026 - Source: - Scripps Research Institute - Summary: - Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically...
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
AI brews a caffeine-powered safety switch for future cell therapies
AI brews a caffeine-powered safety switch for future cell therapies Gaby Clark Scientific Editor Robert Egan Associate Editor For many of us, a warm cup of coffee is how we start our day. For Texas A&M Health researchers, it may also offer a new way to control engineered cells in future medicines. A team at the Texas A&M Health Institute of Biosciences and Technology has developed an artificial intelligence-designed molecular switch that uses caffeine to rapidly separate engineered proteins...
Popular joint supplement glucosamine linked to faster Alzheimer’s progression
Popular joint supplement glucosamine linked to faster Alzheimer’s progression - Date: - June 10, 2026 - Source: - UF Health - Summary: - A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why. - Share: A widely used supplement marketed for...
Cancer’s favorite escape trick may actually make it easier to kill
Cancer’s favorite escape trick may actually make it easier to kill - Date: - June 4, 2026 - Source: - Baylor College of Medicine - Summary: - Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Hayley's husband escalated abuse during her pregnancy. Her story is not uncommon
Domestic violence escalated during Hayley's pregnancy — a time when women are at greater risk Wed 10 Jun 2026 at 11:58am When Hayley was pregnant, her husband insisted on attending her medical appointments. But his motivations were not supportive in nature.
This common amino acid helped mice survive deadly inflammation
This common amino acid helped mice survive deadly inflammation A simple amino acid helped infected mice survive by turning the kidneys into powerful defenders against deadly inflammation. - Date: - June 1, 2026 - Source: - Salk Institute - Summary: - A Salk Institute study found that a simple dietary amino acid, methionine, dramatically improved survival in mice facing severe infections and inflammatory conditions.