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Sprinkling 1 simple ingredient over chicken before cooking makes it taste better
Sprinkling 1 simple ingredient over chicken before cooking makes it taste better A simple kitchen cupboard ingredient can transform bland chicken into a flavourful dish Chicken ranks among Britain's most beloved dinner options, yet drawing out the very best flavour from it can sometimes prove trickier than expected. The good news is that food experts say one simple ingredient found in many kitchen cupboards could make a remarkable difference. According to spice experts at Spices Inc,...
Spider webs capture hidden fungal diversity in Thai rice fields
Spider webs capture hidden fungal diversity in Thai rice fields Lisa Lock Scientific Editor Robert Egan Associate Editor A new study published in the open-access Biodiversity Data Journal suggests that spider webs—particularly those incorporating environmental debris—can serve as natural, non-destructive collectors of fungal material in agricultural ecosystems. The findings show that viable fungi can be recovered from these structures, including lineages that may represent previously...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
The Trump Administration Is Done With Social Science
In the summer of 1945, four days after Japan’s official surrender and a few weeks into the Atomic Age, President Harry Truman began floating the idea of an agency guided by “the free intelligence of the scientist” that would fund investigations into how the world works. As of 2024, the agency that Truman had envisioned, the National Science Foundation, supplied about one in every 10 federal research dollars going to U.S. universities. Its Social, Behavioral, and Economic Sciences division...
Lignin to adipic acid in a high-yield chemical and biological redox process
Abstract Viable manufacturing pathways to produce bio-based chemicals from renewable feedstocks, such as lignin derived from plant biomass, are needed to decarbonize the chemicals manufacturing sector. Converting the recalcitrant lignin polymer to valuable bioproducts remains a longstanding challenge in biorefining, with the highest reported single-product yield from lignin currently around 20 wt% (refs. Most existing lignin depolymerization strategies target aryl–ether bond cleavage, which...