the Nucleotide Transformer
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$p$-adic Bi-Filtrations for Topological Machine Learning on Genomic Sequences
arXiv:2606.06117v1 Announce Type: cross Abstract: We introduce pVR, a topological machine learning framework for alignment-free genomic sequence classification that combines $p$-adic numbers with topological data analysis. Each DNA sequence is encoded along two complementary axes: a $p$-adic distance on $k$-mer prefixes, which captures hierarchical positional structure, and a compositional $L_1$ distance on $k$-mer frequencies, which captures local sequence content. The two distances jointly...
LDARNet: DNA Adaptive Representation Network with Learnable Tokenization for Genomic Modeling
Announce Type: new Abstract: Genomic foundation models increasingly adopt large language model architectures, yet almost universally rely on fixed tokenization schemes such as $k$-mers, BPE, or single nucleotides, which impose arbitrary sequence boundaries that may obscure biologically relevant structure. We present LDARNet, a 120M-parameter hierarchical genomic foundation model that adapts H-Net-style dynamic chunking from autoregressive generation to masked language modeling, combining...
Overlooked DNA structures help organize the genome
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A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it
In a first, scientists translated an entire viral genome so a quantum computer could read and analyze it Scientists have uploaded a viral genome to a quantum computer, marking an important step for the future of quantum-enabled advancements in biology. Scientists say they have uploaded a real genome to a quantum computer for the first time, marking an important step in applying the emerging technology to biology. The researchers encoded the entire genome of the hepatitis D virus (HDV) onto a...
DNA had one rule. Bacteria didn’t get the memo
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Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.