vSub

Paraventricular thalamus gates hippocampal coding of salient experiences.

Adaptive behavior requires neural circuits that encode salient stimuli to guide approach and avoidance. The hippocampal ventral subiculum (vSub) encodes information related to avoidance and reward seeking, yet how upstream inputs shape its representations of salient appetitive and aversive events remains unclear. Here, we show that a projection from the anterior paraventricular thalamus (PVT) to vSub carries an aversive state signal that biases vSub representations toward threat related...