Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
Science
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Key Points
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.