Streptomyces
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Related Articles from SNS
A global regulatory atlas of Streptomyces reveals conserved and diversified transcriptional networks across actinomycetes
Transcriptional regulatory networks determine how bacteria integrate environmental signals with growth, metabolism and stress adaptation. Actinomycetes encode exceptionally large repertoires of transcription factors (TFs) coordinating morphological development, environmental adaptation and specialized metabolism, yet their regulatory networks remain poorly defined. Here, we apply DNA affinity purification sequencing (DAP-seq) to 789 predicted TFs of Streptomyces coelicolor, generating...
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
How drought rewires roots, cutting iron uptake across major food crops
How drought rewires roots, cutting iron uptake across major food crops Sadie Harley Scientific Editor Robert Egan Associate Editor New research by scientists at the University of Calgary has found that plants, ranging from canola to rice to tomatoes, actively shut down their own ability to take up iron when they experience drought. It's a finding that could have implications for the nutritional value of agricultural crops. The study, published in the journal Cell, questions whether plants...
Using protein language models for pangenome construction
Current pangenome construction methods rely largely on nucleotide or protein sequence alignment, limiting their ability to detect remote orthologs and semantic relations. We introduce a novel method that leverages protein language model embeddings to capture functional and semantic relationships beyond sequence similarity. Our approach employs approximate nearest-neighbor search coupled with a clustering step utilizing HDBSCAN, DBSCAN, or weighted single-linkage clustering with multiple...