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Brazil’s Embraer sees eventual China breakthrough for E2 jets
Brazilian planemaker Embraer expects to eventually bring its E2 jets into China, seeing a role for the aircraft among the country’s domestically developed models, a senior executive told Reuters on Sunday. “We have a dedicated team in Beijing, they’re day-to-day working in China,” Embraer Commercial Aviation CEO Arjan Meijer said on the sidelines of a global gathering of top airline executives in Rio de Janeiro. “We believe the E2 family is the ideal complement to the indigenous products...
Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD
Duchenne muscular dystrophy (DMD) presents a critical therapeutic gap in adolescent patients, where fibro-fatty muscle replacement and depletion of the regenerative niche render existing interventions insufficient. Prostaglandin E2 signaling through the EP4 receptor stimulates muscle regeneration, but systemic off-target effects have limited clinical translation of EP4 agonism. We evaluated irodanoprost (IROD), a bone-targeted prodrug of an EP4-selective agonist, in a DMD rat model using...
Cocktail of the week: Circle 13’s cherry kalimotxo – recipe | The good mixer
Circle 13 is featuring a new cocktail, the cherry kalimotxo, as their cocktail of the week. This lower-ABV highball combines cherry cola, red wine, and an artichoke aperitif. It is a popular choice at their park takeovers and reflects their Basque-inspired kitchen.
A thalamus–brainstem attractor network drives history-biased decisions
Abstract Natural environments often change gradually, making it adaptive to bias decisions on the basis of the recent past — a phenomenon known as serial dependence1,2,3. Large-scale recordings during behaviour have identified that serial dependence is a common motif for decision-making, with neural representations of past experiences found throughout the brain4,5,6,7,8,9,10,11. However, it remains unclear whether this bias arises from dedicated neural circuits with history-specific...
Benzothiazole Derivatives as Dual Modulators of PGE2 and GABAergic Signaling in Skeletal Muscle
Benzothiazoles are attractive scaffolds for small-molecule modulators of neuronal signaling. However, their impact on skeletal muscle and GABAergic pathways remains poorly understood. We synthesized a focused library of benzothiazole derivatives via oxidative electrophilic substitution and profiled their activity in C2C12 skeletal muscle cells, assessing cytotoxicity, proliferation, myogenic differentiation, and GABA-related signaling using cell-based assays, real-time PCR, and transcriptomics.