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New social features further Plex’s evolution from media server business
Plex is adding new social features to the platform. As of today, users can make and share "personalized lists on Plex of any movie, show or episode," the company said in an announcement. Later this year, users will be able to import lists from other streaming services and react to other people's lists.
Compositional and interpretable representation of histology using AI foundation models and sparse autoencoders
Light microscopy of tissue sections stained with hematoxylin and eosin (H&E) has been the foundation of histopathology for over 150 years and remains essential for diagnosis and research. The development of high-plex spatial profiling approaches able to measure protein and RNA expression at single-cell resolution augments but does not replace H&E imaging, even in research. Computational pathology (CPath) models based on deep learning promise to further increase the value of H&E...
Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis
Tertiary lymphoid structures (TLSs) are sites of immune organization in peripheral tissues that arise from chronic inflammation. They play important roles in infection control and cancer but the mechanisms controlling their formation remain only partly understood. Here, we combine high-plex imaging, serial-section 3D reconstruction, and optimal transport trajectory modeling to reconstruct TLSs in human lungs infected with Mycobacterium tuberculosis.
Cell type-centric interaction networks define spatial architecture of intrahepatic cholangiocarcinoma
Tumor spatial organization critically shapes disease progression and therapeutic response, yet remains poorly defined. Intrahepatic cholangiocarcinoma (iCCA), a rare and aggressive liver malignancy with extensive stromal and immune remodeling, provides a compelling model to study tumor architecture. We generated a single-cell spatial atlas of 1 million cells from 131 iCCA patients using 53-plex spatial proteomics.
Blockbuster new Raspberry Pi project turns any screen into old-school VCR
I love Star Trek so much. I’ve watched most Trek series multiple times over the decades, and was shocked when, on my most recent watch of The Next Generation, I noticed something: High definition upscaling makes the show look way worse. Old-school 4:3 CRT television screens with their low resolution hid a lot of stuff, like tape on the Enterprise set doors that hid whatever names were stenciled on them for prior episodes, which are glaringly present on modern editions of the show.
UMITIC: An unsupervised framework for the joint characterization of cellular phenotypes and spatial neighborhoods in multiplex and hyperplex immunofluorescence imaging data
Multiplexed imaging technologies enable the simultaneous measurement of dozens of protein markers while preserving context, providing a high-resolution view of tissue organization schemes. However, extracting meaningful insights from these high-dimensional datasets--particularly in hyperplex settings (>20 markers)--remains a major computational challenge, especially in the absence of annotated data. Here, we present UMITIC (Unsupervised Analysis of Multiplex Images via TIssue...
Competing Auctions in Intermediated Markets
arXiv:2606.06633v1 Announce Type: new Abstract: We analyze competing auctions in intermediated markets, where a seller selects among parallel mechanisms for the sale of a single good, most prominently the relay-and-protocol architecture of proposer-builder separation in Ethereum. When the intermediary can enforce single-homing on its bidders, sealed-bid second-price intermediary auctions fully unravel into the sealed first-price principal auction; open bidding-format intermediaries unravel...
No Glastonbury, no problem: Here are eight European music festivals you can still book this summer
Most of Europe's music festivals have sold out, but there are plenty you can still get tickets for across the continent. Primavera Sound is already in the rear-view mirror. Glastonburyis taking 2026 off for one of its regular fallow years.