Rachel Walters
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Why The Macallan remains one of the world’s most coveted single malt whiskies
Why The Macallan remains one of the world’s most coveted single malt whiskies From sherry-seasoned oak casks in Spain to its striking Speyside distillery, The Macallan has built a whisky world around patience, provenance and luxury. Scotland has always known how to command the global stage, lending its dramatic landscapes and finest exports to everything from Hollywood blockbusters to peak-TV dramas. At The Macallan Estate, that cinematic prestige is palpable.
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.