Ribosome
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Related Articles from SNS
Ribosome tunnel interactions reveal how bacteria can pause protein production
Ribosome tunnel interactions reveal how bacteria can pause protein production Lisa Lock Scientific Editor Robert Egan Associate Editor How do bacteria regulate the production of their proteins? Researchers at the University of Hamburg, in collaboration with international partners, have now demonstrated how small protein building blocks, known as peptides, specifically influence bacterial protein production. The findings have been published in two articles in the journal Nature Communications.
Nanopore Direct RNA Sequencing Enables Reproducible, Site-Resolved Pseudouridine Quantification in Human Ribosomal RNA
Pseudouridine is the most abundant post-transcriptional modification in human ribosomal RNA, with over 110 annotated sites and variable stoichiometry across biological contexts. Existing quantification methods are low-throughput or constrained to predefined panels. We benchmarked nanopore direct RNA sequencing using the Dorado v5.1 model against mass spectrometry-validated sites in human liver tissue, induced pluripotent stem cells, and HeLa cells.
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
Amino Acid Stress Induces Non-AUG Initiation of c-myc Translation
Initiation of translation at non-AUG start codons can generate novel isoforms of important cellular regulators, with activities or localization distinct from their AUG-initiated counterparts. Ribosomes scanning the 5'UTR upstream of canonical AUG starts recognize near-cognate starts inefficiently, however, and the mechanisms by which non-canonical starts might be regulated physiologically are poorly understood. We show here that the restriction of utilization of individual amino acid induces...
Stability distillation hypothesis for the origin of life
arXiv:2403.17072v5 Announce Type: replace Abstract: The logical chain of this paper proceeds as follows: differential stability leads to the spontaneous emergence of information, which enables the physical selection of RNA, followed by compartmentalization as a computational platform, then non-genetic information accumulation in metabolic networks, ribosomal assembly from cross-catalytic modules, and ultimately the co-origin and coexistence of cells and viruses. Each link in this chain...
Microbial Dynamics Across Commercial Spaceflights of Varying Duration
Spaceflight introduces environmental stressors that can alter human microbiomes and immune responses. We analyzed 259 biospecimens from six astronauts across two commercial ISS missions: Axiom 2 (10-day mission) and Axiom 3 (21-day mission). Samples included saliva, stool, urine, and body swabs from 10 anatomical sites, profiled via 16S ribosomal RNA (rRNA) gene sequencing.
Stability distillation hypothesis for the origin of life
arXiv:2403.17072v4 Announce Type: replace Abstract: The logical chain of this paper proceeds as follows: differential stability leads to the spontaneous emergence of information, which enables the physical selection of RNA, followed by compartmentalization as a computational platform, then non-genetic information accumulation in metabolic networks, ribosomal assembly from cross-catalytic modules, and ultimately the co-origin and coexistence of cells and viruses. Each link in this chain...
Saturday Citations: Failure to launch; cellular mortality; heavy weather
May 30, 2026 report Saturday Citations: Failure to launch; cellular mortality; heavy weather Chris Packham Author Lisa Lock Scientific Editor Robert Egan Associate Editor Highlights from the last week of May, 2026: A key climate tipping point is disrupting the Arctic Ocean food chain (more of a lowlight, I guess). Scuba-diving tourism may not be the benefit to coral reef systems that we once thought, and might actually be unsustainable.
A prognostic human brain network for diffuse midline glioma
Abstract Diffuse midline gliomas (DMGs) are near-universally lethal tumours of the childhood central nervous system1,2. In animal models, DMGs form brain-wide integrated networks through neuron-to-glioma synapses3,4,5,6 and glioma-to-glioma gap junctional coupling3. This extensive connectivity robustly promotes the growth and invasion of DMG3,4,5,6,7,8,9 and other glial malignancies10,11,12 through paracrine mechanisms and direct neuron-to-glioma synapses.
A 5.3-million-year-old deep-sea whale necropolis in the Diamantina Zone
Abstract Whale falls are biodiversity oases at seabeds1,2,3,4,5,6, yet their record from the oceans has remained sparse and fragmentary6,7. Here we report the discovery of a vast whale necropolis in the Diamantina Zone (4,616- to 7,001-m depth), extending about 1,200 km along the sea floor of the southeastern Indian Ocean. This area has a deep and extensive accumulation comprising five modern natural whale-fall communities and 476 fossil cetaceans recorded.