Saccharomyces
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Related Articles from SNS
Old Yellow Enzyme from Brevibacillus nitrificans functions as 12-oxo-phytodienoic acid reductase in planta
Old Yellow Enzymes (OYEs) are a widely distributed family of ene-reductases that were first described in a Saccharomyces cerevisiae ferment. In plants, cis-12-oxo-phytodienoic acid (cis-OPDA) reductase (OPR) is the best studied OYE. In Arabidopsis thaliana, the peroxisomal AtOPR3 was characterized as the major OPDA reductase, which generates 3-oxo-2-(2-pentenyl)-cyclopentane-1-octanoic acid in the jasmonic acid (JA) biosynthesis.
DNA Replication under Thermal, Chemical, and Genotoxic Stress
arXiv:2606.08138v1 Announce Type: new Abstract: Eukaryotic DNA replication must remain robust under thermal, chemical, and genotoxic stress despite large fluctuations in replication dynamics. Here, we develop a lattice-based stochastic Monte Carlo framework for whole-genome replication in Saccharomyces cerevisiae at single base-pair resolution, incorporating probabilistic origin firing, replication fork-speed distributions, and a time-dependent limiting factor that governs the availability...
Gene ancestries reveal diverse microbial associations during eukaryogenesis
Abstract The origin of eukaryotes remains a central enigma in biology1. Continuing debates agree on the pivotal role of a symbiosis between an alphaproteobacterium and an Asgard archaeon2,3. However, the nature, timing and contributions of other potential bacterial partners4,5,6 and the role of interactions with viruses7,8,9 remain contentious.
Coupled intracellular redox and extracellular respiration sensing for quantitative oxidative stress profiling
Abstract Quantitative assessment of cellular oxidative stress requires simultaneous measurement of intracellular redox state and extracellular respiratory activity, yet integrated sensing approaches remain limited. Here, we present a dual fluorescent sensing platform combining a genetically encoded redox biosensor (roGFP2-Tsa2{Delta}CR) with an optical oxygen sensor embedded in microwell plates for parallel, noninvasive quantification of intracellular reactive oxygen species (ROS) and oxygen...
Yeast experiments reveal an evolutionarily conserved backup route for making a molecule that's essential to life
Yeast experiments reveal an evolutionarily conserved backup route for making a molecule that's essential to life Lisa Lock Scientific Editor Robert Egan Associate Editor Hiroshima University researchers say a newly proposed three-step "detour" pathway for making dolichol, a molecule cells need to properly process proteins, may be more universal than scientists realized. Experiments in yeast suggest eukaryotes may rely on overlapping biochemical pathways, including the evolutionarily...
Correcting for Global Synonymous Selection Improves the Accuracy of Episodic Positive Selection Inference
The ratio of nonsynonymous to synonymous substitution rates ({omega}) constitutes a fundamental parameter for inferring adaptive protein evolution, predicated upon the assumption that synonymous substitutions are selectively inert. This premise, however, is increasingly untenable given evidence of selection acting on synonymous substitutions, driven by various biological processes such as translational efficiency and mRNA stability. In this study, we demonstrate that unmodelled synonymous...