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Meet the CEO of Section L, the apartment-hotel brand that’s rethinking extended stays in Japan
Meet the CEO of Section L, the apartment-hotel brand that’s rethinking extended stays in Japan Tested by fire through the COVID-19 pandemic, Section L is all about breezy extended stays that feel like home, enhanced by efficient technology. Section L’s colourful website with cheeky photos of travellers crossing roads in Pokemon garb and blowing bubbles in bed gives a hint of what to expect when you stay with the Japanese apartment-hotel brand. Co-founder and CEO Howard Ho opened Section L in...
Bill aims to end H-1B route to Green Cards & cut OPT: What the new act proposes
US lawmaker Chip Roy has introduced a bill aimed to overhaul the H-1B hiring programme titled “American White-Collar Worker Jobs Act of 2026”. Among other changes, the bill seeks to end the use of H-1B visas as a pathway to permanent residency ( Green Card) and eliminates the Optional Practical Training (OPT) program to prioritize employment opportunities for American STEM professionals. Publishing an official release, the Republican lawmaker said that the proposed legislation "would reform...
A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases
Abstract Nuclear receptors are central regulators of metabolism1, yet therapeutic strategies that enforce continuous receptor activation frequently lead to reduced efficacy and unacceptable toxicity. Here we report a first-principles drug design strategy that aligns pharmacokinetics with physiological signalling cycles. We developed linafexor, a potent non-bile-acid agonist of the farnesoid X receptor (FXR)2; it is engineered for rapid systemic clearance, which enables pulsatile receptor...
Show HN: Keybench – Scriptable, extensible performance tool for key value stores
guycipher/keybench Folders and files | Name | Name | Last commit date | || |---|---|---|---|---| Repository files navigation keybench ======== A scriptable, extensible performance tool for sorted key value stores.
Quantifying thermal-signature equivalence in infrared breast thermography using a modified Pennes bioheat model
arXiv:2605.05713v2 Announce Type: replace Abstract: Infrared breast thermography provides a noninvasive measurement of skin-surface temperature, but the relation between surface thermal patterns and intratumoral physiology is limited by heat diffusion and thermal screening. Here we study a steady-state modified Pennes bioheat model in a two-dimensional multilayer breast-tissue cross-section containing a finite-sized tumor with spatially heterogeneous perfusion. We compare four idealized...
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis
Abstract Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis1,2. Whether lifestyle alters CH clone expansion or the phenotypic programming of CH mutant cells, thereby affecting atherosclerosis, is unknown. Here, in humans and mice and across mutations in Jak2, Tet2, Trp53 and Dnmt3a, we demonstrate mutation-dependent responses to sleep and exercise in CH and show that mutant cells are uniquely sensitive to lifestyle.
Mitochondria directly interact with the nuclear pore complex
Abstract Mitochondria regulate cellular processes through direct and indirect interactions with other organelles. A well-studied example has been contact with the endoplasmic reticulum at mitochondrial-associated endoplasmic reticulum membranes1, which control pathways including redox and calcium homeostasis2,3. Recent studies have also reported direct mitochondria–nuclear membrane contacts in cancer cells and yeast that promote pro-survival signalling4,5.
Light-induced quantum friction of carbon nanotubes in water
Abstract Friction slows down moving objects at both macroscopic and microscopic scales1. At the electronic level, quantum friction describes direct transfer of momentum between a liquid and the electrons of a solid2. Owing to its microscopic nature, this phenomenon remains experimentally challenging to capture3.
Test-case reducers are underappreciated debugging tools
Test-case reducers are less well known than they should be, and those who are aware of them don’t always realise the variety of ways we can use – perhaps even abuse! – them. In this post, I’m going to explore some of the things I’ve learnt while using these wonderful tools. I’ll start at the basics, because the idea is so simple that it can be hard to believe it works.
Whole-genome duplication shaped cell-type evolution in the vertebrate brain
Abstract The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution1, but it is unclear whether the duplicated genes (ohnologues) facilitated cell-type evolution. Here using brain single-cell transcriptomes from five chordates—human2, mouse3, lizard4, lamprey5 and amphioxus—we report that many cell-type families with conserved core transcription factors in vertebrates do not show...