Aβ
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Related Articles from SNS
Aβ Aggregates Bind the U1 Spliceosomal Ribonucleoprotein in Alzheimer Disease Brain
Missplicing due to U1 small nuclear ribonucleoprotein (U1 snRNP) insolubilization and dysfunction has been identified in Alzheimer disease (AD) brain. Cytoplasmic aggregation and mislocalization of the U1 snRNP partly co-localizes with tau neurofibrillary tangles, and some evidence for tau-U1 binding has been identified. However, tau-U1 co-localization by immunohistochemistry is only partial, and insoluble U1 small nuclear RNA (snRNA) binding proteins correlate better with A{beta} than with...
Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.
Apolipoprotein E (APOE) associates with amyloid plaques A{beta} in Alzheimer disease (AD). The {epsilon}4 allele of apolipoprotein E (APOE{epsilon}4) is the strongest genetic risk factor for sporadic AD and exacerbates A{beta} plaque burden relative to APOE{epsilon}3 and APOE{epsilon}2. The majority of ApoE associates with multiple lipid classes to form lipoproteins both in the brain and the periphery.