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Related Articles from SNS
CREP: Cis-Regulatory Element Predictor Based on Fine-Tuned Enformer
A substantial fraction of disease-associated genetic variants reside in non-coding regions of the genome, where they act by perturbing cis-regulatory elements (CREs) such as enhancers, promoters, and insulators. While recent sequence-based deep learning models, such as Enformer, accurately predict continuous epigenomic signals from DNA sequence, they do not directly provide discrete and interpretable CRE annotations. Here, we present CREP (Cis-Regulatory Element Predictor), a fine-tuned...
Annotation-Informed Block-Sparse Bayesian Modeling for cis-Expression Prediction
arXiv:2606.00483v1 Announce Type: cross Abstract: Genotype-based cis-expression prediction depends on accurately modeling local regulatory architecture. We present block-sparse Bayesian sparse linear mixed model (bsBSLMM), an extension of Bayesian sparse linear mixed model (BSLMM) that incorporates linkage disequilibrium (LD)-block spike-and-slab sparsity and a transcription start site (TSS)-informed SNP inclusion prior. Across 23,098 genes from GEUVADIS European-ancestry lymphoblastoid cell...
Training-Free Coverless Multi-Image Steganography with Access Control
Announce Type: replace Abstract: Coverless Image Steganography (CIS) hides information without explicitly modifying a cover image, providing strong imperceptibility and inherent robustness to steganalysis. However, existing CIS methods largely lack robust access control, making it difficult to selectively reveal different hidden contents to different authorized users. Such access control is critical for scalable and privacy-sensitive information hiding in multi-user settings.
Old Yellow Enzyme from Brevibacillus nitrificans functions as 12-oxo-phytodienoic acid reductase in planta
Old Yellow Enzymes (OYEs) are a widely distributed family of ene-reductases that were first described in a Saccharomyces cerevisiae ferment. In plants, cis-12-oxo-phytodienoic acid (cis-OPDA) reductase (OPR) is the best studied OYE. In Arabidopsis thaliana, the peroxisomal AtOPR3 was characterized as the major OPDA reductase, which generates 3-oxo-2-(2-pentenyl)-cyclopentane-1-octanoic acid in the jasmonic acid (JA) biosynthesis.
Biological Reasoning-Informed Regression for Interpretable Regulatory DNA Activity Prediction
arXiv:2606.08147v1 Announce Type: cross Abstract: DNA cis-regulatory elements (CREs) such as enhancers control gene expression levels. Accurately predicting regulatory activity from DNA sequences is valuable but challenging, as it requires understanding complex biological regulatory processes. Existing methods typically regress activity scores from sequences in a black-box manner, limiting both interpretability and regression performance.
Spaniards now spend half their salary on rent, study finds
A property portal study finds the average share of salary spent on housing has risen 12 points since 2019, with Madrid and Catalonia leading on 70% of pay. The evidence of the housing crisis Spain is facing is plain for all to see. In the rental market, rents have risen by around 30% since 2022, according to the CIS, while new housing construction - PwC data - has been stuck at record lows since 2010, averaging 83,000 homes a year compared with 315,000 on average between 1970 and 2010.
Immune context unmasks regulatory effects of Neanderthal and Denisovan introgression
Neanderthal and Denisovan introgression have left a pervasive footprint in the human genome, yet its regulatory consequences remain poorly understood. Here we use a massively parallel reporter assay to characterize the cis-regulatory activity of 4,161 high-frequency introgressed variants across respiratory (A549), hepatic (HepG2), and hematopoietic (K562) cells exposed to immune and infectious stimuli. We find that ~18% of variants show differential activity between archaic and modern...
Cell-type-resolved genetic variation shapes inflammatory bowel disease risk
Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10627-zSingle-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.
'Dumbass' criminal breaks the 'first rule of ransomware club'
Even ransomware cartels make mistakes, and in this case, it was a biggie that could have landed the responsible crim in a Russian gulag: accidentally infecting a company located in a Commonwealth of Independent States country. In what threat-hunter Dominic Alvieri deemed the ransom “dumbass of the day,” Nova, the affiliate program for ransomware crew RAlord, on Tuesday issued an apology to Eriell Group, a major oilfield services company with headquarters in Uzbekistan and a corporate office...
Trichome and inflorescence evolution in the paleopolyploid tree genus Greyia Hook. & Harv.
The southern African endemic tree genus Greyia Hook. & Harv. (Francoaceae, Geraniales) comprises three species distinguished by striking variation in trichome morphology and floral architecture, yet the genomic and regulatory basis of these traits has remained largely unexplored. Here, we present chromosome-scale genome assemblies for all recognized Greyia species, namely Greyia radlkoferi, Greyia sutherlandii, and Greyia flanaganii, providing the first high-quality genomic resources for...