FLIM
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Related Articles from SNS
Open-source FLIM Playground could speed reproducible analysis of complex cell images
Modern fluorescence microscopy can generate images of living cells as stunning to look at as they are informative to study. For techniques like fluorescence lifetime imaging microscopy (FLIM), those images provide a window into cell metabolism, helping scientists study cancer treatment, autoimmune disease and more.
Split intein vectors permit oversize FLIM-FRET biosensor neuronal expression
Adeno-associated virus (AAV) packaging limits constrain the design, performance, and in vivo application of genetically encoded biosensors. We developed a split intein-mediated reconstitution strategy enabling modular delivery and reassembly of oversized fluorescence lifetime-based biosensors. Using this platform, we engineered an oversized cAMP sensor compatible with one-photon fluorescence lifetime measurements, enabling monitoring of intracellular signaling dynamics in distinct neuronal...
Lipidated ApoE is found in nanoscale proximity to Aβ aggregates in human Alzheimer brains.
Apolipoprotein E (APOE) associates with amyloid plaques A{beta} in Alzheimer disease (AD). The {epsilon}4 allele of apolipoprotein E (APOE{epsilon}4) is the strongest genetic risk factor for sporadic AD and exacerbates A{beta} plaque burden relative to APOE{epsilon}3 and APOE{epsilon}2. The majority of ApoE associates with multiple lipid classes to form lipoproteins both in the brain and the periphery.